Alternative fat: redefining adipocytes for biomanufacturing cultivated meat.

Trends Biotechnol

Bioengineering Systems Division, Institute of Bioengineering and Bioimaging (IBB), A*STAR, 31 Biopolis Way #07-01, Singapore 138669; Current address: Cell Biology and Therapies Division, Institute of Molecular and Cell Biology (IMCB), A*STAR, 61 Biopolis Drive #07-04 Proteos, Singapore 138673.

Published: May 2023

Cellular agriculture provides a potentially sustainable way of producing cultivated meat as an alternative protein source. In addition to muscle and connective tissue, fat is an important component of animal meat that contributes to taste, texture, tenderness, and nutritional profiles. However, while the biology of fat cells (adipocytes) is well studied, there is a lack of investigation on how adipocytes from agricultural species are isolated, produced, and incorporated as food constituents. Recently we compiled all protocols related to generation and analysis of adipose progenitors from bovine, porcine, chicken, other livestock and seafood species. In this review we summarize recent developments and present key scientific questions and challenges that need to be addressed in order to advance the biomanufacture of 'alternative fat'.

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http://dx.doi.org/10.1016/j.tibtech.2022.08.005DOI Listing

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