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A Case Report of Breakthrough Infections With 2 SARS-CoV-2 Variants in a Lung Transplant Patient. | LitMetric

AI Article Synopsis

  • * The clinical symptoms associated with the Omicron infection were more severe compared to the Delta infection, raising concerns about its impact on lung transplant patients.
  • * The study calls for further investigation into the effects of new COVID-19 variants on lung transplant patients and suggests keeping a cautious approach until more data is available.

Article Abstract

A lung transplant (LT) patient developed 2 distinct episodes of COVID-19, confirmed by whole-genome sequencing, which was caused by the Delta, and then followed 6 weeks later, by the Omicron variant. The clinical course with Omicron was more severe, leading us to speculate that Omicron may not be any milder among LT patients. We discuss the potential mechanisms behind the Omicron not being any milder among LT patients and emphasize the need for outcomes data among these patients. Until such data become available, it may be prudent to maintain clinical equipoise as regards the relative virulence of the newer variants among LT patients.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314265PMC
http://dx.doi.org/10.1016/j.transproceed.2022.07.003DOI Listing

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