AI Article Synopsis
- Biodegradable natural polymers, specifically composite microspheres made from calcium alginate, silk fibroin peptide, and Bletilla striata polysaccharide, were developed for wound dressing using the reverse emulsion method.
- Microspheres significantly enhance platelet aggregation and boost red blood cell aggregation rates while also enabling rapid thrombosis, crucial for wound healing.
- Tannic acid-loaded microspheres showed effective antibacterial properties, improved fibroblast survival, reduced inflammation, and achieved over 92.80% wound closure within 7 days, indicating strong potential for rapid wound healing and hemostasis treatment.
Article Abstract
Biodegradable natural polymers are receiving increasing attention as potential candidates for wound dressing. In the present study, composite microspheres (mCSB) based on calcium alginate (CA), silk fibroin peptide (SP), and Bletilla striata polysaccharide (BSP) were prepared by the reverse emulsion method. The excellent swelling properties of microspheres enable them to rapidly promote thrombosis. Microspheres can increase the platelet aggregation index to 1.5 and the aggregation rate of red blood cells to as high as 80 %. Furthermore, tannic acid (TA)-loaded microspheres demonstrate a slow-release effect on TA; this allows the microspheres to exhibit good long-lasting antibacterial properties. Due to the synergistic effects of SP and TA, the cell senescence was delayed, with a 126.69 % survival rate of fibroblasts after 3 days of incubation. In addition, TA led to a rapid reduction in inflammation levels, with a wound closure rate of >92.80 % within 7 days. The multifunctional TA-loaded mCSB has great application potential for rapid wound healing and the treatment of wound hemostasis.
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| http://dx.doi.org/10.1016/j.ijbiomac.2022.09.123 | DOI Listing |
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