Forty-nine of 52 (94.2%) children with musculoskeletal infection (MSKI) were successfully treated with cefadroxil dosed at 30 mg/kg/day over a 10-year time period. Two failures were associated with poor medication adherence. Our study suggests that treatment of MSKI with cefadroxil offers acceptable outcomes. Confirmation through clinical trials is appropriate.
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http://dx.doi.org/10.1093/jpids/piac104 | DOI Listing |
Antimicrob Agents Chemother
May 2024
University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, Colorado, USA.
J Pediatric Infect Dis Soc
December 2022
Division of Pediatric Infectious Diseases, UPMC Children's Hospital of Pittsburgh, USA.
Forty-nine of 52 (94.2%) children with musculoskeletal infection (MSKI) were successfully treated with cefadroxil dosed at 30 mg/kg/day over a 10-year time period. Two failures were associated with poor medication adherence.
View Article and Find Full Text PDFMicrobiol Spectr
August 2022
University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, Colorado, USA.
Cephalexin and cefadroxil are oral first-generation cephalosporins used to treat methicillin-susceptible Staphylococcus aureus (MSSA) infections. Despite its shorter half-life, cephalexin is more frequently prescribed, although cefadroxil is an appealing alternative, given its slower clearance and possibility for less frequent dosing. We report comparative MIC distributions for cefadroxil and cephalexin, as well as for oxacillin, cephalothin, ceftaroline, and cefazolin, for 48 unique clinical MSSA isolates from pediatric patients with musculoskeletal infections.
View Article and Find Full Text PDFIran J Microbiol
April 2021
Department of Microbiology, School of Medicine, Universitas Udayana, Bali, Indonesia.
Background And Objectives: is a Gram-negative organism causing mild to severe infections, with a wide spectrum range of organs involved. The study aimed to describe antibiotics susceptibility of from clinical specimens from October 11, 2019 to September 11, 2020.
Materials And Methods: Study was conducted retrospectively in a private microbiology laboratory in Mataram Indonesia.
J Med Case Rep
November 2017
Department of Anesthesiology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN, 55905, USA.
Background: Although spinal infections have been reported following dental procedures, development of a spinal infection attributed to poor dentition without a history of a dental procedure in an immunocompetent adult has not been previously reported. Here we provide a case report of a multilevel lumbar spine infection that developed in an immunocompetent adult with poor dentition.
Case Presentation: A 63-year-old white male man with past medical history of hypertension presented to a hospital emergency department with a 4-month history of progressively worsening low back pain.
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