Forty-nine of 52 (94.2%) children with musculoskeletal infection (MSKI) were successfully treated with cefadroxil dosed at 30 mg/kg/day over a 10-year time period. Two failures were associated with poor medication adherence. Our study suggests that treatment of MSKI with cefadroxil offers acceptable outcomes. Confirmation through clinical trials is appropriate.

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http://dx.doi.org/10.1093/jpids/piac104DOI Listing

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Article Synopsis
  • Cephalexin is the primary oral treatment for children with musculoskeletal infections caused by MSSA, while cefadroxil offers a viable alternative due to its longer half-life.
  • A study compared the pharmacokinetics (PK) and pharmacodynamics (PD) of cephalexin and cefadroxil, finding that both antibiotics met PD targets for effectiveness against MSSA in pediatric patients.
  • Cefadroxil, requiring less frequent dosing, could be a preferred choice for oral step-down therapy in treating serious MSSA infections in children.
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Forty-nine of 52 (94.2%) children with musculoskeletal infection (MSKI) were successfully treated with cefadroxil dosed at 30 mg/kg/day over a 10-year time period. Two failures were associated with poor medication adherence.

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Cephalexin and cefadroxil are oral first-generation cephalosporins used to treat methicillin-susceptible Staphylococcus aureus (MSSA) infections. Despite its shorter half-life, cephalexin is more frequently prescribed, although cefadroxil is an appealing alternative, given its slower clearance and possibility for less frequent dosing. We report comparative MIC distributions for cefadroxil and cephalexin, as well as for oxacillin, cephalothin, ceftaroline, and cefazolin, for 48 unique clinical MSSA isolates from pediatric patients with musculoskeletal infections.

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Background And Objectives: is a Gram-negative organism causing mild to severe infections, with a wide spectrum range of organs involved. The study aimed to describe antibiotics susceptibility of from clinical specimens from October 11, 2019 to September 11, 2020.

Materials And Methods: Study was conducted retrospectively in a private microbiology laboratory in Mataram Indonesia.

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Background: Although spinal infections have been reported following dental procedures, development of a spinal infection attributed to poor dentition without a history of a dental procedure in an immunocompetent adult has not been previously reported. Here we provide a case report of a multilevel lumbar spine infection that developed in an immunocompetent adult with poor dentition.

Case Presentation: A 63-year-old white male man with past medical history of hypertension presented to a hospital emergency department with a 4-month history of progressively worsening low back pain.

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