AI Article Synopsis
- ASAP1, a protein linked to cancer, is found to be expressed more in various cancers, particularly in hepatocellular carcinoma (HCC), suggesting its potential as a prognostic marker.
- In a study of 149 HCC tissue samples, high expression of ASAP1 was linked to male gender, advanced tumor grade, vessel invasion, and higher cancer stages.
- Increased ASAP1 expression correlated with poorer overall survival and recurrence-free survival in HCC patients, indicating it could serve as a significant prognostic biomarker for this type of cancer.
Article Abstract
The expression of ArfGAP with SH3 domain ankyrin repeat and PH domain 1 (ASAP1) is increased in various types of cancer, showing potential as a prognostic marker. The clinicopathological implications of ASAP1 expression in patients with hepatocellular carcinoma (HCC) remain unclear. We thus investigated the clinicopathological significance and prognostic effect of ASAP1 expression in HCC patients. ASAP1 expression was assessed in 149 HCC tissue samples using immunohistochemistry (IHC). The associations between ASAP1 expression and clinicopathological characteristics were analyzed. The prognostic effect of ASAP1 expression in patients with HCC was evaluated based on survival analyses and confirmed using a web-based tool. ASAP1 expression was observed in the cytoplasm of tumor cells. High ASAP1 expression was observed in 89 (59.7%) of 149 cases. High ASAP1 expression was significantly associated with male patients ( = 0.018), higher histological grade ( = 0.013), vessel invasion ( = 0.021), and higher stage ( = 0.020). High ASAP1 expression was associated with shorter overall survival (OS; = 0.041) and recurrence-free survival (RFS; = 0.008) based on Kaplan-Meier survival analyses. Web-based analysis using Kaplan-Meier (KM) plotter showed high mRNA ASAP1 expression to be associated with short OS ( = 0.001). High ASAP1 expression was associated with aggressive clinicopathological characteristics and poor clinical outcomes in patients with HCC. ASAP1 can be considered a prognostic biomarker in HCC patients.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9468229 | PMC |
| http://dx.doi.org/10.3389/pore.2022.1610635 | DOI Listing |
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