AI Article Synopsis
- Two new macrolide metabolites, phthoramycins B and C, were discovered from Streptomyces sp. HU210.
- Their structures were determined using advanced techniques like NMR and mass spectrometry.
- Both compounds exhibited moderate cytotoxic effects against specific human cancer cell lines, K562 and A549.
Article Abstract
Two new 22-membered macrolide metabolites, phthoramycins B (1) and C (2), were isolated from the fermentation broth of Streptomyces sp. HU210. Their structures were elucidated based on extensive spectroscopic techniques including 1D, 2D NMR and HRESIMS data. Compounds 1 and 2 showed moderate cytotoxic activity against human leukemia cell line K562 and lung carcinoma cell line A549.
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| http://dx.doi.org/10.1038/s41429-022-00563-1 | DOI Listing |
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