A multifunctional FeO@MoS@SDS Z-scheme nanocomposite: NIR enhanced bacterial inactivation, degradation antibiotics and inhibiting ARGs dissemination.

To fight the flourishment of drug-resistant bacteria caused by antibiotics and the dissemination of antibiotic resistance genes (ARGs), it is of great urgency to develop multifunctional non-antibiotic agents with residual antibiotics elimination, and ARGs dissemination inhibition properties. Herein, sodium dodecyl sulfate (SDS) was modified onto the surface of FeO @MoS by ultrasonic method to obtain the Z-scheme, multifunctional FeO @MoS @SDS nanocomposites. The FeO @MoS @SDS (weight ratio of FeO @MoS and SDS was 1:1) was selected as the optimal agent. Under NIR irradiation, the FeO @MoS @SDS had a photothermal conversion efficiency of 45.96%, and could generate plenty of reactive oxygen species (ROS) at the same time. Under the synergy of photothermal and photodynamic, the antibacterial efficiency of FeO @MoS @SDS to E. coli, MRSA and P. aeruginosa could reach 99.95%, 99.97% and 99.58%, respectively, indicating excellent photothermal-photodynamic therapy (PPT) effect. The FeO @MoS @SDS also displayed photocatalytic activity in degradation of tetracycline (TC). The degradation rate of TC could reach 92.3% after 2 h of visible light irradiation. The obtained results indicated that a promising FeO @MoS @SDS composite based multifunctional nanoplatform could be constructed for NIR induced bacterial inactivation, antibiotics degradation and ARGs dissemination inhibition.