Antimicrobials have been fed to livestock for more than 60 years. Veterinarians and producers saw tremendous gains in health and performance, and usage became widespread. Over time, improved management reduced some of the benefit of many feed-through antimicrobials except for a few important diseases. As a result of concerns about antimicrobial resistance, the US FDA restricted the use of medically important antimicrobials. Starting in 2017, medically important antimicrobials were restricted to therapeutic purposes only, and only under the order of a veterinarian. The aim of this review is to provide an overview of commonly used antimicrobials in livestock feed and regulatory changes regarding the veterinary feed directive. When used judiciously, in-feed antimicrobials are an important tool to ensure the health and welfare of food animals while preserving the effectiveness for animals and humans.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2460/javma.22.07.0300 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Immunogenicity of Type IV Pilin Proteins from in Chickens.
Microorganisms
January 2025
Chaire en recherche avicole et Centre de Recherche en Infectiologie Porcine et Aviaire (CRIPA), Département de sciences cliniques, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, QC J2S 2M2, Canada.
, the causative agent of necrotic enteritis in chickens, is controlled by in-feed antibiotics. With increasing pressure to reduce antimicrobial use, the development of alternative preventive tools is needed. Type IV pili proteins have been shown to be immunogenic in many Gram-positive bacteria.
View Article and Find Full Text PDFSelf-Assembled Peptide Hydrogels PPI45 and PPI47: Novel Drug Candidates for Infection Treatment.
Gels
January 2025
Gene Engineering Laboratory, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
, a prevalent zoonotic pathogen, poses a significant threat to skin wound infections. This study evaluates the bactericidal efficacy of self-assembled peptide hydrogels, PPI45 and PPI47, derived from the defensin-derived peptide PPI42, against ATCC43300. The high-level preparation of PPI45 and PPI47 was achieved with yields of 1.
View Article and Find Full Text PDFMuscle biochemistry and residue accretion in male Oreochromis niloticus fries administered therapeutic, subtherapeutic and overdoses of dietary oxytetracycline.
Fish Physiol Biochem
January 2025
Aquatic Animal Health and Environment Division, ICAR-Central Institute of Brackishwater Aquaculture, Raja Annamalai Puram, Chennai, 600028, Tamil Nadu, India.
Oxytetracycline (OTC), an approved antibiotic for aquaculture, is under strict control and regulatory endeavour. This study compared the effects of oral administration of graded doses of OTC comprising the therapeutic (80 mg/kg biomass/day), subtherapeutic (40 mg) and overdoses (240, 400 and 800 mg) in male Nile tilapia Oreochromis niloticus fries (0.64 ± 0.
View Article and Find Full Text PDFA pilot study on the effects of in-feed probiotic ATCC 53103 (LGG) on vaccinated Atlantic salmon (): microbiomes and challenge resilience.
Can J Microbiol
January 2025
Agriculture and Agri-Food Canada, Lacombe Research and Development Centre, Lacombe, AB T4L 1W1, Canada.
The use of probiotics is an alternative approach to mitigate the proliferation of antimicrobial resistance in aquaculture. In our study, we examined the effects of GG (ATCC 53103, LGG) delivered in-feed on the weight, length, skin mucus, and faecal microbiomes of Atlantic salmon. We also challenged the salmon with 2004-05MF26 (Asal2004) and assessed the mortality.
View Article and Find Full Text PDFMolecular responses to clove and oregano essential oils are associated with reduced inflammation and improved gut barrier function in broiler chickens.
Poult Sci
December 2024
Animal Bioscience and Biotechnology Laboratory United States Department of Agriculture-Agricultural Research Service, Beltsville Agricultural Research Center, Beltsville, MD 20705, USA. Electronic address:
In vitro tests were conducted to characterize the host-mediated responses of chickens to Clove Essential Oil (CEO) and Oregano Essential Oil (OEO). Chicken macrophage cells (CMCs), chicken intestinal epithelial cells (IECs), quail muscle cells (QMCs), and chicken embryonic muscle cells (EMCs) were utilized in these assays. EMCs were collected from the 13-day-old embryo during egg incubation and all cell lines were seeded at 2 × 10/mL in a 24-well plate.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!