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Slow Waning of Antibodies Following BNT162b2 as a Third Dose in Adults Who Had Previously Received 2 Doses of Inactivated Vaccine. | LitMetric
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Slow Waning of Antibodies Following BNT162b2 as a Third Dose in Adults Who Had Previously Received 2 Doses of Inactivated Vaccine.

Benjamin J Cowling Samuel M S Cheng Mario Martín-Sánchez Niki Y M Au Karl C K Chan John K C Li Lison W C Fung Leo L H Luk Leo C H Tsang Dennis K M Ip Leo L M Poon Gabriel M Leung J S Malik Peiris Nancy H L Leung

J Infect Dis

World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China.

Published: January 2023

We administered BNT162b2 as a third dose to 314 adults aged ≥30 years who had previously received 2 doses of inactivated vaccine. We collected blood samples before the third dose and again after 1 month and 6 months, and found robust antibody responses to the ancestral strain at 6 months after receipt of BNT162b2. Antibody responses to Omicron BA.2 by live virus neutralization were weaker after the third dose and had declined to a low level by 6 months.

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 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9494487PMC
http://dx.doi.org/10.1093/infdis/jiac380DOI Listing

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