Superficial CD34-positive fibroblastic tumor (SCPFT) is a recently described rare superficial mesenchymal tumor. SCPFT has a distinctive morphologic appearance, marked by significant nuclear pleomorphism, low mitotic rate, and diffuse CD34 positivity. SCPFT is underdiagnosed because of its rarity and misdiagnosis as sarcoma, with very few reported cases of local recurrence or metastasis. Recognition and awareness of SCPFT are essential for accurate diagnosis and appropriate clinical management. We describe here the case of a 37-year-old male who presented with a right calf mass diagnosed as SCPFT with subsequent local recurrence of the tumor.
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http://dx.doi.org/10.1111/cup.14329 | DOI Listing |
J Cutan Pathol
December 2024
Department of Pathology and Laboratory Medicine, Hartford Hospital, Hartford, Connecticut, USA.
Superficial CD34-positive fibroblastic tumor (SCD34FT) is a relatively uncommon soft tissue neoplasm, first identified in 2014 and included in the latest, fifth edition of the World Health Organization Soft Tissue and Bone Tumors Classification. A subset of SCD34FTs that exhibit PRDM10 rearrangement may overlap with other PRDM10-rearranged soft tissue tumors, suggesting a shared pathogenic pathway. We report a case of a 16-year-old patient, one of the youngest diagnosed, with an SCD34FT on the forearm, featuring both PRDM10 rearrangement and a unique, diffuse expression of cytokeratin (CK AE1/AE3).
View Article and Find Full Text PDFDiagn Cytopathol
January 2025
Department of Surgery, Maulana Azad Medical College, New Delhi, India.
Superficial CD34-positive fibroblastic tumor (SPFT) is an extremely rare neoplasm of borderline (intermediate) category. To the best of our knowledge, less than 40 cases have been reported in the English literature. It is imperative to understand and emphasize its cytological features as fine needle aspiration cytology (FNAC) is still considered a first line of investigation in such cases in many countries including India.
View Article and Find Full Text PDFAsian J Surg
September 2024
Department of Pathology, The First People's Hospital of Zigong, Sichuan Province, China. Electronic address:
Virchows Arch
November 2024
Department of Pathology, Charles University, Faculty of Medicine in Plzen, Medical Faculty and Charles University Hospital Plzen, Alej Svobody 80, 323 00, Plzen, Czech Republic.
The section on mesenchymal tumors in the 5th edition of WHO classification of skin tumors has undergone several changes, the most important of which is the inclusion of newly identified tumor entities, which will be the main focus of this review article. These specifically include three novel cutaneous mesenchymal tumors with melanocytic differentiation, and rearrangements of the CRTC1::TRIM11, ACTIN::MITF, and MITF::CREM genes as well as EWSR1::SMAD3-rearranged fibroblastic tumors, superficial CD34-positive fibroblastic tumors, and NTRK-rearranged spindle cell neoplasms. Some of the other most important changes will be briefly mentioned as well.
View Article and Find Full Text PDFSkin Res Technol
September 2024
Department of Dermatology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
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