This manuscript is devoted to investigate the mathematical model of fractional-order dynamical system of the recent disease caused by Corona virus. The said disease is known as Corona virus infectious disease (COVID-19). Here we analyze the modified SEIR pandemic fractional order model under nonsingular kernel type derivative introduced by Atangana, Baleanu and Caputo ([Formula: see text]) to investigate the transmission dynamics. For the validity of the proposed model, we establish some qualitative results about existence and uniqueness of solution by using fixed point approach. Further for numerical interpretation and simulations, we utilize Adams-Bashforth method. For numerical investigations, we use some available clinical data of the Wuhan city of China, where the infection initially had been identified. The disease free and pandemic equilibrium points are computed to verify the stability analysis. Also we testify the proposed model through the available data of Pakistan. We also compare the simulated data with the reported real data to demonstrate validity of the numerical scheme and our analysis.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9476458 | PMC |
http://dx.doi.org/10.1007/s11517-022-02661-6 | DOI Listing |
Alzheimers Dement
December 2024
Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, USA.
Background: In the context of pathological aging and Alzheimer's disease (AD), the overexpression of calcineurin has been identified as a factor linked to astrocyte reactivity, neuronal death, and inflammation. This suggests that inhibiting calcineurin or downstream nuclear factor of activated T cells (NFAT) signaling could be a promising strategy for preventing or slowing down AD pathophysiology.
Method: Baseline and annual MRI sessions including higher-order diffusion-weighted imaging was performed over four years on 43 dogs ranging from 5 to 8.
Alzheimers Dement
December 2024
Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA.
Background: To be successful, recruitment registries must retain participants until they can be recruited to studies. Yet, strategies and tactics to improve retention in online recruitment registries remain understudied. This study seeks to quantify the preferences of registry participants' when it comes to video message content aimed at increasing registry renewal.
View Article and Find Full Text PDFBackground: White matter hyperintensities (WMHs) are age-related radiological abnormalities indicative of small vessel disease. It is unclear if WMHs in different regions represent similar pathophysiology and etiology. Here, we developed a framework to estimate WMH pathophysiology in vivo, which allowed us to precisely characterize spatial patterns of WMH tissue alterations associated with four disorders.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Ohio State University Wexner Medical Center, Columbus, OH, USA.
Background: TAR DNA-binding protein 43 (TDP-43), has been shown to be involved in various neurodegenerative disorders involving axonal damage including ALS, FTLD, and LATE. Studying the relationships between postmortem TDP-43 and antemortem white matter (WM) structural integrity can allow for a better understanding of underlying neural mechanisms of the disease. Measures of white matter integrity assume fiber bundles to maintain similar characteristics along the length of the tract, however, advanced computational research has identified that white matter integrity varies in stereotyped patterns along the tract.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Douglas Mental Health University Institute, Montreal, QC, Canada.
Background: White matter hyperintensities (WMHs) are age-related radiological abnormalities indicative of small vessel disease. It is unclear if WMHs in different regions represent similar pathophysiology and etiology. Here, we developed a framework to estimate WMH pathophysiology in vivo, which allowed us to precisely characterize spatial patterns of WMH tissue alterations associated with four disorders.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!