Diphenhydramine overdose with neuromuscular excitation.

Clin Toxicol (Phila)

Department of Emergency Medicine, Division of Medical Toxicology, Oregon Health and Science University, Portland, OR, USA.

Published: November 2022

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http://dx.doi.org/10.1080/15563650.2022.2121717DOI Listing

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Diphenhydramine (DPH), a readily available first-generation H1 receptor antihistamine, can have severe consequences when taken in excessive amounts and can lead to grave outcomes such as seizures, dysrhythmias, coma, and death. Recognizing the early signs and symptoms of DPH toxicity is crucial. Fortunately, fatal adult cases of DPH overdose are rare.

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Introduction: Tricyclic antidepressants often cause drug-induced QRS complex prolongation in overdose but are now less commonly prescribed. We sought to determine, among a contemporary cohort of patients, the pharmaceuticals independently associated with QRS complex prolongation in acute overdose.

Methods: We performed secondary analysis of data from the Toxicology Investigators Consortium (ToxIC) Core Registry.

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