Introduction: Allogeneic hematopoietic stem cell transplantation (allo-HSCT), including human leukocyte antigen-matched sibling donor transplantation and alternative donor transplantation, remains a curative approach for patients with ALL. In recent years, the advent of targeted therapy and immunotherapy has changed the transplant indications of ALL, which can also be combined with allografting to further improve transplant outcomes, especially for those with refractory or relapsed ALL.
Areas Covered: In this review, we summarized the current status of allo-HSCT for ALL, mainly focusing on transplant indications, donor selection, conditioning regimens, graft-versus-host disease prophylaxis, incorporation of targeted immunotherapy with allografting, and measurable residual disease-directed intervention for transplant outcome improvement. We also discussed challenges, such as post-HSCT leukemia relapse treatment and new strategies for complication-related mortality, as well as future directions of allo-HSCT for ALL.
Expert Opinion: Allo-HSCT remains one of the curable therapies for ALL in the era of targeted therapy and immunotherapy. Future directions should focus on decreasing relapse mortality and nonrelapse mortality to further improve the outcomes of patients with ALL.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/17474086.2022.2125375 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Speech Technology for Automatic Recognition and Assessment of Dysarthric Speech: An Overview.
J Speech Lang Hear Res
January 2025
Centre for Language Studies, Radboud University, Nijmegen, the Netherlands.
Purpose: In this review article, we present an extensive overview of recent developments in the area of dysarthric speech research. One of the key objectives of speech technology research is to improve the quality of life of its users, as evidenced by the focus of current research trends on creating inclusive conversational interfaces that cater to pathological speech, out of which dysarthric speech is an important example. Applications of speech technology research for dysarthric speech demand a clear understanding of the acoustics of dysarthric speech as well as of speech technologies, including machine learning and deep neural networks for speech processing.
View Article and Find Full Text PDFBeliefs About Autonomic Arousal Sensations Help Explain Differences in Paraphilic Interests in Young Men and Women.
Arch Sex Behav
January 2025
School of Psychology, University of Ottawa, 136 Jean-Jacques Lussier, Ottawa, ON, K1N 6N5, Canada.
We examined whether beliefs about autonomic arousal sensations and sexual sensation seeking explain some of the gender differences in self-reporting paraphilic sexual interests in 672 university students. A serial mediation model was used to test the direct association of gender and the indirect associations of positive interpretations of autonomic arousal sensations and sexual sensation seeking on paraphilic sexual interests. Anxiety sensitivity (e.
View Article and Find Full Text PDFMetabolic Profiling: A Perspective on the Current Status, Challenges, and Future Directions.
Methods Mol Biol
January 2025
Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College, London, UK.
Metabolic profiling continues to develop, and research is now conducted on this topic globally in hundreds of laboratories, from small groups up to national centers and core facilities. Here we briefly provide a perspective on the current status and challenges facing metabolic phenotyping (metabonomics/metabolomics) and consider future directions for this important area of biomarker and systems biology research.
View Article and Find Full Text PDFAdvances, Challenges, and Opportunities in Plasmonic Nanogap-Enhanced Raman Scattering with Nanoparticles.
ACS Nano
January 2025
Department of Chemistry, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul 08826, South Korea.
Surface-enhanced Raman scattering has been widely used for molecular/material characterization and chemical and biological sensing and imaging applications. In particular, plasmonic nanogap-enhanced Raman scattering (NERS) is based on the highly localized electric field formed within the nanogap between closely spaced metallic surfaces to more strongly amplify Raman signals than the cases with molecules on metal surfaces. Nanoparticle-based NERS offers extraordinarily strong Raman signals and a plethora of opportunities in sensing, imaging and many different types of biomedical applications.
View Article and Find Full Text PDFPlasma alpha-synuclein predicts cognitive impairment in Parkinson's disease: a systematic review and meta-analysis.
J Neurol
January 2025
Faculty of Medicine, University of New South Wales, Sydney, Australia.
Background: Alpha-synuclein (ɑ-syn) plays a key role in Parkinson's disease (PD) pathogenesis, but existing studies have found mixed results regarding the associations between plasma ɑ-syn and the development of cognitive impairment. We aim to clarify the potentially important relationship between ɑ-syn level in plasma and development of cognitive impairment in PD through systematic review and meta-analysis.
Methods: A systematic search was conducted in the PubMed, Embase and Web of Science databases for studies reporting plasma ɑ-syn concentrations and cognitive impairment in PD.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!