Equine pituitary somatotropin (growth hormone) has been studied by zero-order and second-order absorption spectroscopy, and by circular dichroism. Difference absorption spectra have also been generated during proteolytic digestion of the hormone. The molar extinction coefficient of the native protein was found to be 16,050 +/- 330 M-1 cm-1 at 278.1 nm. Comparison of the conformations of equine somatotropin and somatotropins isolated from several other mammalian species indicates a close structural relationship between these molecules. With the increasing number of species which have been studied, it is becoming evident that with regard to conformation, the somatotropins can be subdivided into at least three major groups.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1399-3011.1987.tb02288.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Objective: Pergolide, labeled for the treatment of pituitary pars intermedia dysfunction, is 90% protein bound and might cause a decrease in blood thyroid hormone concentrations by displacing them from binding proteins. This study investigated the effect of pergolide on the equine thyroid function.
Methods: This was an analytic, observational, cohort study.
Distribution and sequence analysis of the melanocortin 2 receptor in horses and ponies.
Domest Anim Endocrinol
January 2025
School of Biology and Environmental Science, Queensland University of Technology, Brisbane, Queensland, Australia. Electronic address:
The melanocortin 2 receptor (MC2R) has relevance to equine pituitary pars intermedia dysfunction (PPID), as it is the primary binding site for ACTH, which circulates at elevated concentrations in animals affected by PPID. Despite this, little is known about MC2R in equine species. The overall aim of this investigation was to determine MC2R mRNA expression in tissues relevant to PPID in healthy horses and to examine the MC2R gene sequence in a cohort of horses and ponies with and without PPID.
View Article and Find Full Text PDFInsulin signaling in insulin-dysregulated Icelandic horses.
Domest Anim Endocrinol
October 2023
Clinic for Horses, University of Veterinary Medicine Hannover, Foundation, Bünteweg 9, Hannover 30559, Germany; Boehringer Ingelheim Vetmedica GmbH, Binger Straße 173, Ingelheim am Rhein 55216, Germany.
The underlying molecular mechanisms leading to insulin dysregulation are poorly understood in horses. Therefore, this study aimed to determine if insulin dysregulation is associated with an altered basal expression and extent of phosphorylation of key proteins of the insulin signaling cascade in liver (LT), muscle (MT), and subcutaneous adipose tissue (AT) under basal and stimulated conditions. Twelve Icelandic horses were subjected (1) to an oral glucose (Gluc PO) challenge and (2) to an intravenous (Ins IV) insulin challenge in a crossover study.
View Article and Find Full Text PDFPeriovulatory anticoagulant therapy enhances embryo recovery rates in superovulated mares.
Theriogenology
January 2025
São Paulo State University, School of Veterinary Medicine and Animal Science, Botucatu, São Paulo, Brazil.
Although protocols for superovulation have been described in horses, this technique has been discouraged due to the low embryo recovery rates in superovulated mares. The reason for these poor results is poorly understood, but the formation of a blood clot in the ovulation fossa following ovulations has been hypothesized. Therefore, this study aimed to assess the safety and effect of periovulatory anticoagulant therapy on embryo recovery of superovulated mares.
View Article and Find Full Text PDFEffect of short-term dopamine reduction on insulin sensitivity and post-prandial insulin and glucose responses in Standardbred horses.
Domest Anim Endocrinol
January 2025
Melbourne Veterinary School, The University of Melbourne, Parkville, Victoria, Australia. Electronic address:
The role of dopamine in the regulation of insulin secretion in horses is poorly understood and requires further investigation. Pituitary pars intermedia dysfunction (PPID) is associated with decreased activity of dopaminergic neurons which normally suppress peptide hormone secretion from the pituitary pars intermedia. A high proportion of horses with PPID also have insulin dysregulation (ID), characterised by post-prandial hyperinsulinaemia and/or tissue insulin resistance, which are risk factors for the development of laminitis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!