AI Article Synopsis
- - Lacosamide is an antiepileptic medication approved by the FDA in 2008, targeting voltage-gated sodium channels to help control seizures.
- - While generally safe and effective, some case reports indicate that lacosamide can cause serious cardiovascular side effects, particularly in patients with existing heart conditions.
- - This report discusses a specific case of life-threatening heart arrhythmia due to lacosamide overdose, which was successfully managed using veno-arterial extracorporeal membrane oxygenation (VA-ECMO).
Article Abstract
Lacosamide is an antiepileptic drug that acts on voltage-gated sodium channels and was approved as an antiepileptic by the Food and Drug Administration in 2008. Although the efficacy and safety of lacosamide have been established in many previous trials, some case reports have shown that it may lead to cardiovascular side effects, especially in patients with electrical conduction system disorders. We herein report a case of life-threatening cardiac arrhythmia caused by lacosamide intoxication that was successfully treated with veno-arterial extracorporeal membrane oxygenation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10183285 | PMC |
| http://dx.doi.org/10.2169/internalmedicine.0145-22 | DOI Listing |
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