AI Article Synopsis
- Researchers found that the fungal pathogen Cryptococcus neoformans uses a secreted protein to influence the immune response.
- This protein activates TLR4 signaling, which helps create an environment favorable for type 2 immunity.
- By promoting type 2 immunity, C. neoformans is able to evade the host's defense mechanisms and continue to grow.
Article Abstract
The invasive fungal pathogen Cryptococcus neoformans promotes type 2 immunity to escape host defenses by unknown mechanisms. In a recent issue of Nature, Dang and colleagues identify a secreted fungal protein that triggers TLR4 signaling and supports a type 2 permissive environment and C. neoformans growth.
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| http://dx.doi.org/10.1016/j.immuni.2022.08.015 | DOI Listing |
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Fooling TLR4 to promote fungal virulence.
Immunity
September 2022
Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address:
Article Synopsis
- Researchers found that the fungal pathogen Cryptococcus neoformans uses a secreted protein to influence the immune response.
- This protein activates TLR4 signaling, which helps create an environment favorable for type 2 immunity.
- By promoting type 2 immunity, C. neoformans is able to evade the host's defense mechanisms and continue to grow.
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