Toddlers in agricultural areas may be athave risk from pesticide exposure . A cross-sectional study was conducted with 130 toddlers and their caregivers. Face-to-face interviews were done to gather information about exposure factors. A wipe sampling technique was used to collect carbamate residues on each toddler's hands and feet. Results showed that there were carbamate residues on all wipe samples (100%), with a median concentration of 30.47 micrograms per sample (hands and feet). Carbamate residues detected on toddlers' hands and feetwere significantly associated (p < 0.05) with many factors, including the toddlers' relationships with caregivers, the education level of caregivers, the household incomes, the gender of toddlers, the frequency of following caregivers to farms, the frequency of foot washing, daytime activities, and playing durations. The health risk from dermal carbamate exposurewas above the acceptable range (HI = 3.244). Preventive measures should be considered to reduce toddlers' pesticide exposure in agricultural areas.
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http://dx.doi.org/10.1080/09603123.2022.2123456 | DOI Listing |
Int J Mol Sci
January 2025
Department of Anatomy, Animal Physiology and Biophysics, Faculty of Biology, University of Bucharest, Splaiul Independentei 91-95, 050095 Bucharest, Romania.
Cenobamate is a new and highly effective antiseizure compound used for the treatment of adults with focal onset seizures and particularly for epilepsy resistant to other antiepileptic drugs. It acts on multiple targets, as it is a positive allosteric activator of γ-aminobutyric acid type A (GABA) receptors and an inhibitor of neuronal sodium channels, particularly of the late or persistent Na current. We recently evidenced the inhibitory effects of cenobamate on the peak and late current component of the human cardiac isoform hNav1.
View Article and Find Full Text PDFAnal Chim Acta
January 2025
School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan, 430205, China. Electronic address:
Background: Carbosulfan (CBS) is a widely used carbamate pesticide in agricultural production, its easy decomposition into hypertoxic carbofuran poses serious threats to human health and food safety. Therefore, sensitive and accurate detection of CBS is of significant importance. Conventional chromatography-based techniques require expensive instruments and complicated sample pretreatment, limiting their application for fast detection.
View Article and Find Full Text PDFAnal Chem
January 2025
Institute of Organic Chemistry, University of Vienna, Währinger Straße 38, 1090 Wien, Austria.
Chemical cross-linking/mass spectrometry (XL-MS) has emerged as a complementary tool for mapping interaction sites within protein networks as well as gaining moderate-resolution native structural insight with minimal interference. XL-MS technology mostly relies on chemoselective reactions (cross-linking) between protein residues and a linker. DSSO represents a versatile cross-linker for protein structure investigation and in-cell XL-MS.
View Article and Find Full Text PDFChemMedChem
December 2024
State Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensor Technology and Health, College of chemistry, Central China Normal University, Wuhan, 430079, P.R. China.
Butyrylcholinesterase plays an indispensable role in organisms, and its abnormal expression poses a significant threat to human health and safety, covering various aspects including liver-related diseases, diabetes, obesity, cardiovascular and cerebrovascular diseases, and neurodegenerative diseases. In addition, toxic substances such as organophosphorus and carbamate pesticides markedly inhibit BChE activity. BChE activity serves as a critical parameter for the clinical diagnosis of acute organophosphorus pesticide poisoning and the evaluation of organophosphorus and carbamate pesticide residues.
View Article and Find Full Text PDFElife
December 2024
Department of Biothermodynamics and Drug Design, Institute of Biotechnology, Life Sciences Center, Vilnius University, Vilnius, Lithuania.
We designed novel pre-drug compounds that transform into an active form that covalently modifies particular His residue in the active site, a difficult task to achieve, and applied to carbonic anhydrase (CAIX), a transmembrane protein, highly overexpressed in hypoxic solid tumors, important for cancer cell survival and proliferation because it acidifies tumor microenvironment helping invasion and metastases processes. The designed compounds have several functionalities: (1) primary sulfonamide group recognizing carbonic anhydrases (CA), (2) high-affinity moieties specifically recognizing CAIX among all CA isozymes, and (3) forming a covalent bond with the His64 residue. Such targeted covalent compounds possess both high initial affinity and selectivity for the disease target protein followed by complete irreversible inactivation of the protein via covalent modification.
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