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Understanding the scale and nature of avoidable healthcare-associated harm for prisoners in England: protocol for a retrospective cross-sectional study.
BMJ Open
December 2024
Centre for Mental Health and Safety, Division of Psychology and Mental Health, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK
Introduction: Around 1 in 20 patients experience avoidable healthcare-associated harm worldwide. Despite longstanding concerns, there is insufficient information available about the safety of healthcare for prisoners. To address this, this study will investigate the scale and nature of avoidable healthcare-associated harm for prisoners in England.
View Article and Find Full Text PDFExtracorporeal Membrane Oxygenation (ECMO) serves as a crucial intervention for patients with severe pulmonary dysfunction by facilitating oxygenation and carbon dioxide removal. While traditional ECMO systems are effective, their large priming volumes and significant blood-contacting surface areas can lead to complications, particularly in neonates and pediatric patients. Microfluidic ECMO systems offer a promising alternative by miniaturizing the ECMO technology, reducing blood volume requirements, and minimizing device surface area to improve safety and efficiency.
View Article and Find Full Text PDFOptimized Prime Editing of Human Induced Pluripotent Stem Cells to Efficiently Generate Isogenic Models of Mendelian Diseases.
Int J Mol Sci
December 2024
Ocular Genomics Institute, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA.
Prime editing (PE) is a CRISPR-based tool for genome engineering that can be applied to generate human induced pluripotent stem cell (hiPSC)-based disease models. PE technology safely introduces point mutations, small insertions, and deletions (indels) into the genome. It uses a Cas9-nickase (nCas9) fused to a reverse transcriptase (RT) as an editor and a PE guide RNA (pegRNA), which introduces the desired edit with great precision without creating double-strand breaks (DSBs).
View Article and Find Full Text PDFGreater than the sum of its parts: multimodality imaging in adults with congenital heart disease.
Cardiovasc Diagn Ther
December 2024
Department of Heart, Vascular & Thoracic, Division of Cardiology & Cardiovascular Medicine - Pediatric Cardiology, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA.
As the population of adults with congenital heart disease (ACHD) grows, there also grows an expanded need for non-invasive surveillance methods to guide management and intervention. A multimodal imaging approach layers complementary insights from echocardiography, computed tomography (CT), magnetic resonance imaging (MRI), and other modalities into a clinician's view of patient physiology. Merely applying strategies from acquired adult cardiac disease would be inadequate and potentially misleading.
View Article and Find Full Text PDFThe most appropriate indicators of successful ovarian stimulation.
Reprod Biol Endocrinol
January 2025
King's College London, London, UK.
Ovarian stimulation (OS) is a crucial component of clinical IVF treatment that strongly influences outcomes. As such, it is useful to understand the indicators for successful OS during IVF. As OS leads to multiple follicular recruitment, it can be quantified as number of oocytes retrieved.
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