d-Limonene administered by oral gavage at 150-2400 mg/kg/day in a subchronic (91-day) study conducted for the National Cancer Institute induced renal alterations in male rats at all dose levels, whereas kidneys of male mice, female rats and female mice were unaffected. The renal alterations were dose responsive, and were similar to changes observed as sequelae to oral or inhalation exposure to decalin, a model compound used in a volatile hydrocarbon toxicology programme. Decalin induces a nephrotoxic response unique to the male rat, but the primary response associated with decalin exposure--hyaline droplet formation within the cytoplasm of the epithelial cells of the proximal convoluted tubule--was not recognized in the kidneys of d-limonene-exposed male rats. A possible explanation for the absence of this primary response from kidneys of the d-limonene-treated male rats could be the 4-5-day interval between administration of the final dose and the killing of the animals.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0278-6915(87)90168-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Acute and chronic cannabis vapor exposure produces immediate and delayed impacts on phases of fear learning in a sex specific manner.
Psychopharmacology (Berl)
January 2025
Hotchkiss Brain Institute, Alberta Children's Hospital Research Institute, Mathison Centre for Mental Health Research and Education, University of Calgary, Calgary, AB, Canada.
Rationale: Current treatment options for PTSD have unreliable efficacy, with many individuals unable to achieve complete remission. Cannabis and cannabinoids that act through the endogenous cannabinoid (endocannabinoid) system to help promote trauma recovery by means of enhanced extinction learning are potential therapeutic, pharmacological candidates. Using a preclinical model of translationally-relevant cannabis administration in rodents, we examined the impact of cannabis exposure on aversive memory.
View Article and Find Full Text PDFChlorantraniliprole (Coragen® 20% SC) exposure induced reproductive toxicity mediated by oxidative stress, apoptosis, and sperm quality deficient in male Wistar rats.
Naunyn Schmiedebergs Arch Pharmacol
January 2025
Zoology Department, Faculty of Science, Cairo University, Giza, Egypt.
Pesticides can adversely affect reproduction by causing congenital abnormalities, fetal demise, and infertility. The reproductive toxicity of coragen, a modified ryanodine receptor-targeting insecticide with chlorantraniliprole concentrations of 20%, was examined in male rats. Twenty-one healthy male rats were randomly assigned to one of three groups: the control group, two orally administered with low (500 mg/kg) and high (1000 mg/kg) doses of coragen for 8 weeks.
View Article and Find Full Text PDFCarboxyl Terminal Modulator Protein Induces Cell Senescence and Is Upregulated With Aging by Zic2 in Rats.
J Cell Physiol
January 2025
Department of Anesthesiology, University of Virginia, Charlottesville, Virginia, USA.
Carboxyl terminal modulator protein (CTMP) may be involved in various physiological and pathological processes, such as inflammation, tumor growth, and cardiac hypertrophy. Our recent study has shown that CTMP is increased with aging and plays a role in determining brain ischemic tolerance. However, it is not known how CTMP expression with aging is regulated and whether the changed CTMP expression has an effect on cell senescence.
View Article and Find Full Text PDFBehavioral mechanisms of oxycodone's effects in female and male rats: II. Reinforcement magnitude and implications for impulsive/risky choice.
J Exp Anal Behav
January 2025
Department of Psychology, University of North Carolina Wilmington, Wilmington, NC, USA.
Rats responded under a concurrent-chains procedure wherein reinforcement magnitude was varied within sessions and oxycodone's effects on sensitivity to magnitude were evaluated in two experiments. In Experiment 1, the alternative providing the larger magnitude was signaled and effects of acute (0.1-1.
View Article and Find Full Text PDFEarly life stress paired with adolescent alcohol consumption reduces two-bottle choice alcohol consumption in mice.
Alcohol Clin Exp Res (Hoboken)
January 2025
Department of Psychology and Center for Neuroscience and Behavior, Miami University, Oxford, Ohio, USA.
Background: In humans, early life stress (ELS) is associated with an increased risk for developing both alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD). We previously used an infant footshock model in rats that produces stress-enhanced fear learning (SEFL) and increases aversion-resistant alcohol drinking to explore this shared predisposition. The goal of the current study was to test the viability of this procedure as a model of comorbid PTSD and AUD in male and female C57BL/6J mice.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!