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Epipharyngeal Abrasive Therapy Down-regulates the Expression of Cav1.2: A Key Molecule in Influenza Virus Entry. | LitMetric

AI Article Synopsis

  • - The study investigates how epipharyngeal abrasive therapy (EAT) affects the expression of the voltage-dependent calcium channel Cav1.2, which is essential for Influenza A virus (IAV) entry into cells, particularly in the ciliated epithelium of the respiratory tract.
  • - It compares two groups of patients: seven who have not undergone EAT and eleven who have, measuring the levels of Cav1.2 using an immunohistochemical score.
  • - Results show that patients treated with EAT had a significantly lower expression of Cav1.2 (4.19 times less), suggesting that EAT might help reduce the risk of IAV infection by modifying the mucosal surface.

Article Abstract

Background/aim: Influenza A virus (IAV) infection causes an inflammatory response to the respiratory mucosa. The viral glycoprotein hemagglutinin (HA) binds to the sialylated voltage-dependent Ca channel (Cav1.2) in ciliated epithelium. The binding of HA and sialylated Cav1.2 is considered essential to IAV infection, entry, and IAV-induced Ca oscillation. The epipharynx comprises the ciliated epithelium, which is the initial target for viruses that cause upper respiratory tract infections. Previously, we showed that epipharyngeal abrasive therapy (EAT), a treatment for chronic epipharyngitis in Japan, which scratches the epipharyngeal mucosa with a cotton swab containing zinc chloride, induces squamous metaplasia. In this study, we evaluated whether squamous metaplasia by EAT affects the expression patterns of Cav1.2.

Patients And Methods: The study subjects were seven patients who had not been treated with EAT and 11 patients who had. For the immunohistochemical assessment of the epipharyngeal mucosa, the staining intensity of Cav1.2 was described using the immunohistochemical score (IHC score).

Results: The IHC scores for Cav1.2 in the EAT-treated group was 4.19-fold lower than those in the non-treated group (p=0.0034).

Conclusion: EAT down-regulates the expression of Cav1.2, a key cell surface molecule in influenza virus entry via squamous metaplasia. Thus, EAT may be a simple method for preventing influenza infection.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463883PMC
http://dx.doi.org/10.21873/invivo.12967DOI Listing

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