AI Article Synopsis
- Magic angle spinning NMR offers a unique way to study the dynamics of biomolecules through rotating frame relaxation measurements.
- The focus is on how motion affects the chemical shift interaction, which is key to understanding relaxation in these experiments.
- Advances in solid state NMR techniques promise improved analysis, allowing researchers to extract important details like motion time scales and activation energy.
Article Abstract
Magic angle spinning NMR rotating frame relaxation measurements provide a unique experimental window into biomolecules dynamics, as is illustrated by numerous recent applications. We discuss experimental strategies for this class of experiments, with a particular focus on systems where motion-driven modulation of the chemical shift interaction is the main mechanism for relaxation. We also explore and describe common strategies for interpreting the data sets to extract motion time scale, activation energy, and angle or order parameters from rotating frame relaxation data. Using model free analysis and numerical simulations, including time domain treatment, we explore conditions under which it is possible to obtain accurate and precise information about the time scales of motions. Overall, with rapid technical advances in solid state NMR, there is a bright future for this class of studies.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10122933 | PMC |
| http://dx.doi.org/10.1021/acs.chemrev.2c00442 | DOI Listing |
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