An efficient and reusable green catalyst for the synthesis of β-aminocarbonyl compounds has been developed. In this new and greener approach, β-aminocarbonyl compounds (1a-1r) were obtained by Montmorillonite K10 clay catalyzed reaction of aryl amines, aliphatic/aromatic aldehydes and β-ketoesters. Molecular docking investigations were performed for all compounds (1a-1r) with the proteins PDB ID: 1JIJ and 1KZN for S. aureus and E. coli, respectively. For all compounds good to strong interactions with the active sites were observed. The biological activities of β-aminocarbonyl compounds were further assessed for their antibacterial and antioxidant activities. The results confirmed that β-aminocarbonyl compounds could be further developed into new drugs with potent antibacterial and antioxidant activities.
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| http://dx.doi.org/10.1002/cbdv.202200669 | DOI Listing |
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