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Oral Administration of the Antimicrobial Peptide Mastoparan X Alleviates Enterohemorrhagic Escherichia coli-Induced Intestinal Inflammation and Regulates the Gut Microbiota.
Probiotics Antimicrob Proteins
February 2024
College of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang, China.
Article Synopsis
- The gut microbiota is crucial for immune system development and can impact inflammation; however, antibiotics can disrupt this balance.
- This study aimed to investigate the anti-inflammatory effects of an antimicrobial peptide called mastoparan X (MPX) when administered orally, specifically looking at its effects in E. coli-infected mice.
- Results showed that MPX helped reduce weight loss and inflammation, improved gut structure, and promoted microbial diversity, highlighting its potential role in managing intestinal inflammation and maintaining gut health.
Interleukin-2/interleukin-6 imbalance correlates with conversion to psychosis from a clinical high-risk state.
Psychiatry Clin Neurosci
January 2023
Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Intelligent Psychological Evaluation and Intervention Engineering Technology Research Center (20DZ2253800), Shanghai Key Laboratory of Psychotic Disorders, Shanghai, China.
Increased interstitial protein because of impaired lymph drainage does not induce fibrosis and inflammation in lymphedema.
Arterioscler Thromb Vasc Biol
February 2013
Department of Biomedicine, University of Bergen, Norway.
Objective: The pathophysiology of lymphedema is incompletely understood. We asked how transcapillary fluid balance parameters and lymph flow are affected in a transgenic mouse model of primary lymphedema, which due to an inhibition of vascular endothelial growth factor receptor-3 (VEGFR-3) signaling lacks dermal lymphatics, and whether protein accumulation in the interstitium occurring in lymphedema results in inflammation.
Methods And Results: As estimated using a new optical-imaging technique, we found that this signaling defect resulted in lymph drainage in hind limb skin of K14-VEGFR-3-Ig mice that was 34% of the corresponding value in wild-type.
[Delirium is a very common and life-threatening condition].
Ther Umsch
February 2010
Medizinische Klinik 2, Schwerpunkt Geriatrie, Klinikum Nürnberg, Deutschland, Lehrstuhl für Geriatrie, Friedrich-Alexander-Universität, Erlangen-Nürnberg.
Although a lot is known regarding the epidemiology and aetiology of this condition, the pathophysiology of delirium remains poorly understood. Today, the leading hypothesized mechanism for the pathogenesis of delirium focuses on a central cholinergic deficiency and dopamine excess. Besides, other neurotransmitters, such as dopamine, serotonin, norepinephrine, glutamate and gamma-aminobutyric acid (GABA) may also contribute to delirium.
View Article and Find Full Text PDF[A case of temporary severe disequilibrium hypercalcemia].
Nihon Ronen Igakkai Zasshi
February 1994
Second Department of Internal Medicine, Osaka City University Medical School.
The patient, a 69-year-old woman, was admitted to Osaka City University Hospital on July 25, 1992, for severe hypercalcemia. Laboratory data on admission revealed severe hypercalcemia of 14.9 mg/dl and renal dysfunction with serum creatinine of 2.
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