AI Article Synopsis
- Miller et al. found no link between clonal hematopoiesis of intermediate potential (CHIP) and increased 28-day mortality from COVID-19, while suggesting IL-6 signaling might indirectly affect patient outcomes.* -
- Ho et al. studied patients with monoclonal gammopathy of undetermined significance (MGUS) and reported that 25% experienced severe COVID-19 infections.* -
- The presence of immunoparesis in MGUS patients was identified as a significant factor associated with worse outcomes in the context of COVID-19.*
Article Abstract
Two Letters to address the risks of COVID-19 in populations with precursors of hematological disease. In the first article, Miller and colleagues report on whether clonal hematopoiesis of intermediate potential (CHIP) is associated with adverse outcomes with COVID-19, finding no association between CHIP and 28-day mortality while providing data indirectly linking IL-6 signaling and patient outcomes. In the second article, Ho and colleagues investigate the outcomes of patients with monoclonal gammopathy of undetermined significance (MGUS) with COVID-19, reporting that one-fourth had a severe infection and that on multivariable analysis, adverse outcomes are more likely if immunoparesis is present.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9474409 | PMC |
| http://dx.doi.org/10.1182/blood.2022017616 | DOI Listing |
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