Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
An Electrochemical Pipette for the Study of Drug Metabolite.
Anal Chem
December 2024
Division of Energy, Matter and Systems, School of Science and Engineering, University of Missouri-Kansas City, Kansas City, Missouri 64110, United States.
Article Synopsis
- * A new thin-layer electrode (TLE) enables flexible experimental designs to observe reaction mechanisms of drug metabolites in a time-sensitive manner, which is crucial for accurate analysis.
- * The TLE, when used with a microelectrode, allows detailed study of drug metabolic oxidation, exemplified by the oxidation of acetaminophen and related drugs, facilitating structural analysis of reaction intermediates and products.
Approved drugs successfully repurposed against based on machine learning predictions.
Front Cell Infect Microbiol
October 2024
Laboratory of Molecular Epidemiology and Experimental Pathology - LR16IPT04, Institut Pasteur de Tunis, Université de Tunis El Manar, Tunis, Tunisia.
Article Synopsis
- Drug repurposing is a cost-effective method to find new treatments for Neglected Tropical Diseases like Leishmaniasis, utilizing existing FDA-approved drugs.
- In a recent study, five out of ten predicted drug candidates showed effective anti-leishmanial properties, with Acebutolol, Prilocaine, and Phenylephrine being newly identified as potential treatments.
- Two compounds, Dibucaine and Domperidone, demonstrated particularly low inhibitory concentrations (IC values), indicating strong antileishmanial activity without significant toxicity to host cells.
Unraveling the molecular basis for effective regulation of integrin α5β1 for enhanced therapeutic interventions.
Biochem Biophys Res Commun
November 2024
Department of Biosciences and Bioengineering, Indian Institute of Technology Roorkee, Roorkee, 247667, Uttarakhand, India. Electronic address:
Cell attachment to the extracellular matrix significantly impacts the integrity of tissues and human health. The integrin α5β1 is a heterodimer of α5 and β1 subunits and has been identified as a crucial modulator in several human carcinomas. Integrin α5β1 significantly regulates cell proliferation, angiogenesis, inflammation, tumor metastasis, and invasion.
View Article and Find Full Text PDFDevelopment of tungsten trioxide nano-flakes intercalated on tannic acid-functionalized reduced graphene oxide for flexible acebutolol sensors.
Talanta
November 2024
School of Chemical Engineering, Yeungnam University, Gyeongsang, 38541, Republic of Korea.
Acebutolol (ACE) is commonly used to treat hypertension and high blood pressure. Large doses of ACE can have adverse effects with potentially life-threatening consequences. It is, therefore, essential to develop a simple, low-cost, reliable, and reproducible device for detecting ACE in biofluids.
View Article and Find Full Text PDFBreakthrough in High-Efficiency Photocatalytic Degradation of Acebutolol by Advanced Binary CeO-MnO Oxide System.
Molecules
June 2024
School of Chemical Engineering, Yeungnam University, 280 Daehak-Ro, Gyeongsan 38541, Republic of Korea.
The sustainable catalytic efficacy of transition metal oxides (TMO) and rare earth element-based oxides positions them as pivotal materials for effectively treating contaminated wastewater. This study successfully synthesized a series of Ce@MnO photocatalysts using a straightforward hydrothermal method. These photocatalysts were thoroughly characterized for their optical properties, structural morphology, and phase purity.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!