Keratoconus is a progressive corneal thinning disorder that can lead to vision loss. In the last 2 decades, corneal crosslinking (CXL) has emerged as an effective method to halt the progression of keratoconus and reduce the number of patients requiring keratoplasty. The procedure has been adopted globally and has evolved to become a part of combination treatments to regularize the cornea and improve visual outcomes. CXL has even been extrapolated in managing other ocular pathologies such as progressive myopia, infectious keratitis, and bullous keratopathy. This review aims to summarize the current role of CXL in keratoconus and its alternative uses, and provide insights into future developments in this fast-developing field.
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http://dx.doi.org/10.1097/APO.0000000000000557 | DOI Listing |
J Contact Lens Res Sci
July 2024
Illinois College of Optometry, Chicago.
Background And Objective: This study determined whether practitioners specializing in keratoconus (KC) adhere to published guidelines for disease management and to what extent comorbid conditions of dry eye, contact lens tolerance, and psychological consequences of KC are formally assessed as part of long-term management.
Materials And Methods: This cross-sectional study used an IRB-approved, Internet-based, REDCap platform. Descriptive statistics are presented.
Eye Contact Lens
January 2025
Lewis Katz School of Medicine at Temple University (F.A.), Philadelphia, PA; and Wilmer Eye Institute (L.D.M., K.B., A.C.), Baltimore, MD.
Objective: To determine if scleral fittings that occur before corneal cross-linking (CXL) are still successful after the procedure.
Methods: This prospective study included seven patients with keratoconus or post-laser-assisted in situ keratomileusis (LASIK) corneal ectasia who were fitted with scleral lenses then underwent CXL. Four patients (six eyes) had keratoconus and three patients (five eyes) had post-LASIK ectasia.
Cureus
December 2024
Department of Ophthalmology, The University of Jordan, Amman, JOR.
We present the case of a 23-year-old male who experienced vision loss in his left eye 15 months after undergoing bilateral transepithelial photorefractive keratectomy (T-PRK). Despite the absence of any significant preoperative topographical risk factors in either eye, corneal ectasia was later confirmed in the left eye, while the right eye remained normal. Subtle asymmetry in topometric indices and a borderline high Index of vertical asymmetry (IVA) reading suggested the possibility of early subclinical keratoconus, potentially increasing the risk of post-refractive ectasia.
View Article and Find Full Text PDFCornea
January 2025
Chongqing Eye and Vision Care Hospital Aier Eye Hospital Group, Yu Zhong, Chongqing, China.
Purpose: A detailed study of the physicochemical properties of SMILE-derived lenticules and evaluation of their drug delivery after loading with silver nanoparticles (AgNPs).
Methods: The lenticules were decellularized and modified with crosslinking concentrations of 0.01 (0.
Int Med Case Rep J
January 2025
Department of Ophthalmology, University of California San Francisco, San Francisco, CA, USA.
Purpose: To compare the outcomes of two different surgical planning strategies for topography-guided repair of post-LASIK ectasia.
Methods: This is a case report of a patient presenting with post-LASIK ectasia. A retrospective chart review was used to collect details of the ophthalmic exam, as well as ocular imaging such as anterior segment optical coherence tomography and Scheimpflug corneal tomography.
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