AI Article Synopsis
- People with type-2 diabetes can have serious skin wounds that don’t heal well because of poor blood flow, even if their larger blood vessels are fine.
- To help these wounds heal, doctors can encourage blood flow by creating new connections in the skin’s blood vessels, a process called arteriogenesis.
- Researchers found that using special gels with proteins that help blood vessel growth can speed up healing in diabetic mice better than traditional treatments.
Article Abstract
Chronic wounds in type-2 diabetic patients present areas of severe local skin ischemia despite mostly normal blood flow in deeper large arteries. Therefore, restoration of blood perfusion requires the opening of arterial connections from the deep vessels to the superficial skin layer, that is, arteriogenesis. Arteriogenesis is regulated differently from microvascular angiogenesis and is optimally stimulated by high doses of Vascular Endothelial Growth Factor-A (VEGF) together with Platelet-Derived Growth Factor-BB (PDGF-BB). Here we found that fibrin hydrogels decorated with engineered versions of VEGF and PDGF-BB proteins, to ensure protection from degradation and controlled delivery, efficiently accelerated wound closure in diabetic and obese db/db mice, promoting robust microvascular growth and a marked increase in feeding arterioles. Notably, targeting the arteriogenic factors to the intact arterio-venous networks in the dermis around the wound was more effective than the routine treatment of the inflamed wound bed. This approach is readily translatable to a clinical setting.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452813 | PMC |
| http://dx.doi.org/10.1177/20417314221119615 | DOI Listing |
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