AI Article Synopsis
- Researchers developed water-soluble flexible organic frameworks (FOFs) with varying pore sizes to encapsulate cationic neuromuscular blocking agents (NMBAs) like rocuronium and vecuronium.
- These FOFs use multivalency interactions to effectively sequester NMBAs in water, preventing them from escaping, and are confirmed to be non-toxic and biocompatible.
- Animal studies showed that FOFs can significantly reverse neuromuscular block, reducing recovery time by 2.6 to 5.7 times compared to a placebo for different NMBAs.
Article Abstract
Supramolecular sequestration and reversal of neuromuscular block (NMB) have great clinical applications. Water-soluble flexible organic frameworks (FOFs) cross-linked by disulfide bonds are designed and prepared. Different linker lengths are introduced to FOFs to give them varied pore sizes. FOFs are anionic nanoscale polymers and capable of encapsulating cationic neuromuscular blocking agents (NMBAs), including rocuronium (Roc), vecuronium (Vec), pancuronium (Panc) and cisatracurium (Cis). A host-guest study confirms that FOFs bind NMBAs in water. The multivalency interaction between FOFs and NMBAs is able to sequester NMBAs, and prevent them from escaping. These FOFs are non-toxic and biocompatible. Animal studies show that FOFs are effective for the reversal of NMB induced by Roc, Vec and Cis, which shorten the time to a train-of-four ratio of 0.9 by 2.6, 3.8 and 5.7-fold compared to a placebo, respectively.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9384803 | PMC |
| http://dx.doi.org/10.1039/d2sc02456j | DOI Listing |
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