We report the development of a one-pot Bunte's reaction-enabled expeditious platform under aqueous conditions for the scalable conversion of sulfonylureas to synthetically versatile thio-sulfonylureas. The reaction was further propagated in the same pot to yield diverse chiral and achiral isothiosulfonyl analogs. The protocol enabled the synthesis of various drug-like molecules and was applied to an enantiomeric synthesis of a cannabinoid receptor antagonist SLV326.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9453971 | PMC |
| http://dx.doi.org/10.1021/acsomega.2c04816 | DOI Listing |
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