Mushrooms and Chinese traditional herbs have bioactive nutraceuticals with multiple therapeutic functions, including antioxidant and antibacterial activities and microbiome modulation properties. Mushroom-derived bioactive compounds are used in medicines for the treatment of neurological disorders with abnormal braingutmicrobiome axis. This study examined the effects of KI Essence extract, a spleen-tonifying formula, on neurite growth, antioxidant activity, hypomyelination modulation, and the microbiome profile in lipopolysaccharide (LPS)-induced maternal immune activation (MIA) offspring. The KI Essence extract induced PC12 cell neurite growth by increasing extracellular signal-regulated kinase (ERK) phosphorylation, promoting 2,2'-diphenyl-1-picrylhydrazyl radical scavenging activity, reducing the level of tert-butylhydroperoxide-induced lipid peroxidation in brain homogenates, protecting PC12 cells from HO-induced cell death (through the inhibition of ERK phosphorylation), alleviating hypomyelination, and downregulating interleukin-1β through LPS-activated microglia production; moreover, the numbers of Enterobacteriaceae Actinobacteria Peptostreptococcaceae Erysipelotrichaceae, and bacteria in MIA offspring increased. In summary, the KI Essence extract promotes neurite outgrowth, alleviates oxidative stress and hypomyelination, and modulates microbiota dysbiosis in MIA offspring.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9453593 | PMC |
| http://dx.doi.org/10.3389/fphar.2022.964255 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Polyphenolic contents, antioxidant, and antimicrobial activities of Saccocalyx satureioides Coss. & Dur. essential oil and methanol extracts.
An Acad Bras Cienc
January 2025
University of M'sila, Department of Microbiology and Biochemistry, University Pole, Road Bordj Bou Arreridj, M'sila 28000, Algeria.
The whole plant Saccocalyx satureioides, an endemic medicinal plant in Algeria, was evaluated for its polyphenolic contents, antioxidant and antimicrobial activities. The polyphenolic contents of the plant methanolic extracts ranged from 170.47 to 285.
View Article and Find Full Text PDFEssential oil and aqueous extract of basil (Ocimum basilicum) in the diet of pacu (Piaractus mesopotamicus).
Braz J Biol
January 2025
Universidade Federal de Mato Grosso do Sul - UFMS, Faculdade de Medicina Veterinária e Zootecnia - FAMEZ, Campo Grande, MS, Brasil.
This study aimed to evaluate the effects of Ocimum basilicum supplementation in the diet for Piaractus mesopotamicus regarding productive performance, intestinal morphology, muscle residue, and hematological changes after simulated transport stress. Juvenile (23 g±0.08, n = 180) were stocked into 300-L tanks in three treatments and six replicates each: a control diet (not supplemented), a diet with 0.
View Article and Find Full Text PDFEvaluation of the antibacterial activity of essential oils from oregano (Origanum vulgare) against Escherichia coli strains isolated from meat products.
Braz J Biol
January 2025
Universidade Federal de Campina Grande - UFCG, Patos, PB, Brasil.
The objective of this study was to analyze the antimicrobial and anti-stick capacity of essential oil extracted from oregano (Origanum vulgare) in relation to various strains of Escherichia coli (Ec 41, Ec 42, Ec 44, Ec 45) isolated from meat products. Techniques such as Determination of Minimum Inhibitory Concentration were used (MIC) and Minimum Bactericidal Concentration (CBM). Furthermore, the method was used disk diffusion method to examine the interaction between O.
View Article and Find Full Text PDF[Serum pharmacochemistry of Panacis Japonici Rhizoma extract based on UPLC-Q-Exactive Orbitrap-MS].
Zhongguo Zhong Yao Za Zhi
December 2024
Thirdgrade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University Yichang 443002, China College of Medicine and Health Sciences, China Three Gorges University Yichang 443002, China.
In this study, the chemical components of Panacis Japonici Rhizoma extract and absorbed components in rats were identified by ultra-high performance liquid chromatography-quadrupole exactive orbitrap mass spectrometry(UPLC-Q-Exactive Orbitrap-MS). The separation was performed by gradient elution on Waters UPLC BEH C_(18) column(2.1 mm×100 mm, 1.
View Article and Find Full Text PDFChemical characterization of Eucalyptus (Eucalyptus globulus) leaf essential oil and evaluation of its antifungal, antibacterial and antioxidant activities.
Cell Mol Biol (Noisy-le-grand)
January 2025
Laboratory of Cellular Toxicology, Faculty of Science, Department of Biology, Badji Mokhtar University, Annaba, Algeria.
Article Synopsis
- The study analyzes essential oil extracted from dry Eucalyptus globulus leaves, focusing on its chemical composition and potential health benefits.
- The oil consists of 20 identified compounds, primarily linalool, and exhibits antifungal properties against Fusarium roseum and antibacterial effects against Pseudomonas savastanoi.
- While it shows moderate antioxidant activity, it differs from typical eucalyptus oils by being a linalool chemotype rather than eucalyptol-dominant.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!