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Biopolymer coating for particle surface engineering and their biomedical applications. | LitMetric

Biopolymer coating for particle surface engineering and their biomedical applications.

Mater Today Bio

Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, 710119, China.

Published: December 2022

AI Article Synopsis

  • Surface engineering using polymeric coatings is crucial for material design, particularly in biomedical applications, as traditional petroleum-based polymers face limitations due to non-biodegradability and poor biocompatibility.
  • There is currently no universal method for modifying particles of various types, necessitating the development of versatile biopolymeric coatings with favorable properties.
  • Recent advancements include using natural polysaccharides, polyphenol-based biopolymers, and proteins for particle surface modification, with applications in drug delivery, cell protection, and antibacterial treatments, though challenges and future research directions remain.

Article Abstract

Surface engineering of particles based on a polymeric coating is of great interest in materials design and applications. Due to the disadvantages of non-biodegradability and undesirable biocompatibility, the application of petroleum-based synthetic polymers coating in the biomedical field has been greatly limited. In addition, there is lack of a universal surface modification method to functionalize particles of different compositions, sizes, shapes, and structures. Thus, it is imperative to develop a versatile biopolymeric coating with good biocompatibility and tunable biodegradability for the preparation of functional particle materials regardless of their surface chemical and physical structures. Recently, the natural polysaccharide polymers (e.g. chitosan and cellulose), polyphenol-based biopolymers (e.g. polydopamine and tannic acid), and proteins (e.g. amyloid-like aggregates) have been utilized in surface modification of particles, and applications of these modified particles in the field of biomedicine have been also intensively exploited. In this review, the preparation of the above three coatings on particles surface are summarized, and the applications of these materials in drug loading/release, biomineralization, cell immobilization/protection, enzyme immobilization/protection, and antibacterial/antiviral are exemplified. Finally, the challenges and the future research directions on biopolymer coating for particles surface engineering are prospected.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9450159PMC
http://dx.doi.org/10.1016/j.mtbio.2022.100407DOI Listing

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