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Mass spectrometry-based shotgun glycomics for discovery of natural ligands of glycan-binding proteins. | LitMetric

Mass spectrometry-based shotgun glycomics for discovery of natural ligands of glycan-binding proteins.

Curr Opin Struct Biol

Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada. Electronic address:

Published: December 2022

AI Article Synopsis

Article Abstract

The non-covalent associations of complex carbohydrates (glycans) with glycan-binding proteins mediate many important physiological and pathophysiological processes. Identifying these interactions is essential to understanding their diverse biological functions and enables the development of new disease treatments and diagnostics. Knowledge of the repertoire of glycans recognized by most glycan-binding proteins and their affinities is incomplete. Mass spectrometry-based screening of natural glycan libraries has emerged as a promising approach to defining the glycan interactome of glycan-binding proteins. Here, we review recent advances in mass spectrometry-based natural library screening that have led to the discovery of glycan ligands of endogenous and exogenous proteins and illuminated their binding specificities.

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Source
http://dx.doi.org/10.1016/j.sbi.2022.102448DOI Listing

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