Photothermal responsive slippery surfaces with switchable superwettability are promising in the fields of biomedicine, self-cleaning, anti-corrosion, and lab-on-a-chip systems. However, the development of a light switchable slippery surface that combines high-performance photothermal materials with hierarchical microstructures of special orientation remains challenging, which limits the applications in anisotropic droplet manipulation. Herein, we demonstrate a photothermal responsive slippery surface based on laser-structured graphene and polyvinylidene difluoride composites (L-G@PVDF) for controllable droplet manipulation. The L-G@PVDF film exhibits high light absorption (∼95.4%) in the visible and NIR region. After lubricating with paraffin, the resultant surface shows excellent self-healing ability and light-responsive wettability change due to the photothermal effect of L-G@PVDF and the hot melting effect of paraffin. Additionally, by introducing anisotropic grooved structures, the paraffin-infused L-G@PVDF surface displays anisotropic wettability that further affects droplet manipulation under light irradiation. Also, the photothermal responsive slippery property endows the paraffin-infused L-G@PVDF surface with excellent anti-frosting and de-icing capability. Moreover, the smart paraffin-infused L-G@PVDF surface can be combined with a microfluidics chip for light-driven automatic sampling. This study offers insight into the rational design of photothermal responsive slippery surfaces for controllable droplet manipulation.
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http://dx.doi.org/10.1016/j.jcis.2022.08.153 | DOI Listing |
Small
January 2025
Department of Clinical Pharmacology, The Second Hospital of Anhui Medical University, Anhui Medical University, Hefei, 230601, P. R. China.
Topical transdermal drug delivery for psoriasis remains a challenge because of the poor solubility of hydrophobic drugs and the limited penetration of the stratum corneum. In this study, a near-infrared (NIR) light-responsive thermosensitive hydrogel (PDLLA-PEG-PDLLA, PLEL)-based drug reservoir is developed that directly incorporated gold nanorods (GNRs) and methotrexate (MTX) in the sol state at low temperature, which is referred to as PLEL@GNR+MTX. The in vitro anti-psoriasis experiment indicated that, GNRs, as photothermal cores of composite hydrogel, not only triggered keratinocyte apoptosis but also promoted MTX release in a synergistic manner.
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January 2025
Bio-Organic Chemistry, Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.
The morphology of nanodrugs is of utmost importance in photothermal therapy because it directly influences their physicochemical behavior and biological responses. However, clarifying the inherent relationship between morphology and the resultant properties remains challenging, mainly due to the limitations in the flexible morphological regulation of nanodrugs. Herein, we created a range of morphologically controlled nanoassemblies based on poly(ethylene glycol)--poly(d,l-lactide) (PEG-PLA) block copolymer building blocks, in which the model photosensitizer phthalocyanine was incorporated.
View Article and Find Full Text PDFChem Commun (Camb)
January 2025
School of Chemistry and Chemical Engineering, Nantong University, Nantong, Jiangsu 226019, P. R. China.
Nanomaterials possess unique size characteristics, enabling them to cross tissue gaps, penetrate the blood-brain barrier and endothelial cells, and release drugs at the cellular level. Additionally, the surface of nanomaterials is readily functionalized, endowing them with good biocompatibility, low biotoxicity, and specific targeting. All these advantages render nanomaterials broad application prospects in tumor therapy.
View Article and Find Full Text PDFInt J Pharm
January 2025
Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang 330004 China; School of Pharmaceutics, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198 China. Electronic address:
The combination of chemotherapy and photothermal therapy not only improves the therapeutic effect but also limits the side effects of drugs. Herein, a multi-responsive dual-modality bone-targeted drug delivery vehicle for the treatment of osteosarcoma was designed by utilizing alendronate sodium as a bone-targeting ligand for the targeted delivery of doxorubicin (DOX) loaded polydopamine nanoparticles (PDA NPs) coated with γ-polyglutamic acid (APC@PDA/DOX NPs). The average size of spherical NPs was 140.
View Article and Find Full Text PDFAdv Healthc Mater
January 2025
Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, 100081, China.
Poor diabetic wound healing poses a critical threat to human health. Excessive oxidative stress and increased susceptibility to bacterial infection are key issues that impede diabetic wound healing. Cerium oxide nanoparticles (CeO NPs) have attracted increasing attention because of their unique antioxidant and antimicrobial properties.
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