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Trends in osteoporosis assessment, diagnosis after fragility fractures, and treatment for hospitalized patients with osteoporosis or fragility fractures between 2012 and 2021.
Arch Osteoporos
January 2025
Department of Endocrinology and Diabetes, Xiamen Clinical Medical Center for Endocrine and Metabolic Diseases, Xiamen Diabetes Institute, The First Affiliated Hospital of Xiamen University, No. 55 Zhenhai Road, Xiamen, 361003, China.
Unlabelled: Our study investigated trends in osteoporosis management in Xiamen from 2012 to 2021, revealing improvements in screening and treatment, although medication use remained low. Additionally, we identified factors that may influence medication use and emphasized the importance of effective osteoporosis management strategies.
Purpose: The goal of the current study is to explore trends in assessment, diagnosis after fragility fractures, and osteoporosis treatment among hospitalized patients in Xiamen, China, between 2012 and 2021.
Zoledronic acid improves periodontal health, reduces serum inflammation, and enhances bone metabolism in postmenopausal osteoporosis complicated by periodontitis.
Am J Transl Res
November 2024
Department of Stomatology, General Hospital of Shenzhen University Shenzhen 518055, Guangdong, China.
Article Synopsis
- The study aimed to assess the impact of zoledronic acid on periodontal health, inflammation, and bone metabolism in postmenopausal osteoporosis patients suffering from periodontitis.
- Out of 113 participants, those treated with zoledronic acid showed significantly better improvements in periodontal indices, decreased inflammatory markers, and enhanced bone mineral density compared to those receiving standard therapy.
- Results indicate that zoledronic acid is effective in improving periodontal health and bone metabolism in this patient group, without a notable increase in adverse effects.
Pregnancy- and Lactation-Associated Osteoporosis: A Literature Review Based on a Clinical Case.
Cureus
November 2024
Orthopedics and Traumatology, Santo António University Hospital Center, Porto, PRT.
Article Synopsis
- Pregnancy- and lactation-associated osteoporosis (PLO) is a rare condition impacting women postpartum, exemplified by a case of a 29-year-old with severe back pain due to vertebral fractures.
- Diagnosis involves ruling out other causes of osteoporosis, with treatment typically including calcium and vitamin D supplements alongside lactation suppression; however, pain may persist even after treatment.
- The condition remains poorly understood, with potential causes including genetic factors and calcium metabolism changes, highlighting the need for early diagnosis and personalized treatment strategies for better patient outcomes.
The Temporal Changes in Ankle Joint Pathology, Pain and Secondary Osteoporosis in Collagen-Induced Arthritis Rats.
J Inflamm Res
November 2024
Basic Laboratory of Integrated Traditional Chinese and Western Medicine, Shanxi University of Chinese Medicine, Jinzhong, 030619, People's Republic of China.
Article Synopsis
- Rheumatoid arthritis (RA) causes synovial inflammation and pain, but patients may still experience pain even if inflammation is controlled.
- In a study using collagen-induced arthritis (CIA) model rats, researchers aimed to assess the relationship between joint inflammation, pain, and bone destruction while identifying optimal drug treatment timing.
- Findings indicated that while joint swelling and inflammation improved over time, bone destruction remained constant, and pain persisted, suggesting that pain and inflammation may not always occur in sync, highlighting post-inflammatory hyperalgesia.
Primary Osteoporosis Induced by Androgen and Estrogen Deficiency: The Molecular and Cellular Perspective on Pathophysiological Mechanisms and Treatments.
Int J Mol Sci
November 2024
Department of Obstetrics and Gynecology, Taipei Tzu-Chi Hospital, The Buddhist Tzu-Chi Medical Foundation, New Taipei City 231, Taiwan.
Primary osteoporosis is closely linked to hormone deficiency, which disrupts the balance of bone remodeling. It affects postmenopausal women but also significantly impacts older men. Estrogen can promote the production of osteoprotegerin, a decoy receptor for RANKL, thereby preventing RANKL from activating osteoclasts.
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