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Positive and negative syndrome scale in forensic patients with schizophrenia spectrum disorders: a systematic review and meta-analysis. | LitMetric

Positive and negative syndrome scale in forensic patients with schizophrenia spectrum disorders: a systematic review and meta-analysis.

Ann Gen Psychiatry

Psychiatric Epidemiology and Evaluation Unit, IRCCS Istituto Centro San Giovanni Di Dio Fatebenefratelli, Via Pilastroni 4, 25125, Brescia, Italy.

Published: September 2022

AI Article Synopsis

  • The study explored the relationship between symptoms of schizophrenia and violence in forensic patients, noting that symptoms can fluctuate during different phases of the illness.
  • Researchers conducted a systematic review and meta-analysis of existing studies, focusing on the Positive and Negative Syndrome Scale (PANSS) to measure symptom levels among forensic and non-forensic patients.
  • Results showed that forensic patients exhibited higher levels of psychopathological symptoms than non-forensic patients, although both groups had mild symptoms overall, indicating the complexity of the relationship between schizophrenia symptoms and violent behaviors.

Article Abstract

Among forensic patients with schizophrenia spectrum disorders, the association between symptomatology and violence is still not entirely clear in literature, especially because symptoms shift both during the acute phase of the illness and after. The aims were to investigate the level of symptomatology in forensic patients and to evaluate if there are differences in the level of symptoms between forensic and non-forensic patients. According to PRISMA guidelines, a systematic search was performed in PubMed, Web of Science, and ProQuest, using the following key words: "forensic" AND "Positive and Negative Syndrome Scale" OR "PANSS". A total of 27 studies were included in the systematic review, while only 23 studies in the meta-analysis. The overall sample included a total of 1702 participants, most commonly male and inpatients in forensic settings. We found that studies with an entirely male sample had significantly lower Positive PANSS ratings than studies with mixed samples. Although both forensic and non-forensic patients were affected by mild psychopathological symptoms, forensic patients presented higher ratings in all four PANSS scales. This meta-analysis shows that forensic patients reported a mild level of symptomatology, as assessed with the PANSS, and therefore might be considered as patients in partial remission. Among patients with schizophrenia, the association between symptoms and violence is very complex: many factors might be considered as key mediators and thus should be taken into account to explain this association. Further studies are needed.Trial registration all materials and data can be found on the OSF framework: https://osf.io/5ceja (date of registration: 8 September 2021).

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9463849PMC
http://dx.doi.org/10.1186/s12991-022-00413-2DOI Listing

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