As psychedelic medicine is becoming mainstream, physicians need to know something about these medications, their indications, contraindications, and potential for research. This article is a brief overview of the subject with some ideas of how psychedelic medicines can impact the practice of Otolaryngology-Head and Neck Surgery.
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| http://dx.doi.org/10.1016/j.otc.2022.06.002 | DOI Listing |
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Effects of ketamine and propofol on muscarinic plateau potentials in rat neocortical pyramidal cells.
PLoS One
January 2025
Department of Molecular Medicine, Brain Signalling Laboratory, Institute of Basic Medical Sciences, Section for Physiology, University of Oslo, Oslo, Norway.
Propofol and ketamine are widely used general anaesthetics, but have different effects on consciousness: propofol gives a deeply unconscious state, with little or no dream reports, whereas vivid dreams are often reported after ketamine anaesthesia. Ketamine is an N-methyl-D-aspartate (NMDA) receptor antagonist, while propofol is a γ-aminobutyric-acid (GABAA) receptor positive allosteric modulator, but these mechanisms do not fully explain how these drugs alter consciousness. Most previous in vitro studies of cellular mechanisms of anaesthetics have used brain slices or neurons in a nearly "comatose" state, because no "arousing" neuromodulators were added.
View Article and Find Full Text PDFMultidimensional Personality Changes Following Psilocybin-Assisted Therapy in Patients With Alcohol Use Disorder: Results From a Double-Blind, Placebo-Controlled Clinical Trial.
Am J Psychiatry
January 2025
Department of Psychiatry, NYU Langone Center for Psychedelic Medicine, NYU Grossman School of Medicine, New York (Pagni, Zeifman, Mennenga, Carrithers, Goldway, O'Donnell, Ross, Bogenschutz); School of Life Sciences, Arizona State University, Tempe (Mennenga); Department of Psychology, New York University, New York (Goldway); Department of Psychiatry and Behavioral Sciences, University of New Mexico School of Medicine, Albuquerque (Bhatt).
Objective: Evidence suggests that psilocybin-assisted therapy (PAT) leads to durable shifts in personality structure. However, such changes have yet to be characterized in disorders of addiction. In this secondary analysis from a randomized controlled trial, the authors examined the effect of PAT on personality dimensions in patients with alcohol use disorder (AUD), hypothesizing that PAT would attenuate personality abnormalities in AUD and that reductions in trait impulsiveness would be associated with lower drinking.
View Article and Find Full Text PDFPsychedelics for the Treatment of Psychiatric Disorders: Interpreting and Translating Available Evidence and Guidance for Future Research.
Am J Psychiatry
January 2025
Department of Psychiatry (McIntyre, Mansur, Rosenblat) and Department of Pharmacology and Toxicology (McIntyre, Mansur, Rosenblat), University of Toronto, Toronto; Brain and Cognition Discovery Foundation, Toronto (Kwan, Teopiz); Faculty of Medicine, University of Ottawa, Ottawa (Kwan); Champalimaud Research and Clinical Center, Champalimaud Foundation, Lisbon (Oliveira-Maia); NOVA Medical School, Faculdade de Ciências Médicas, NMS, FCM, Universidade NOVA de Lisboa, Lisbon (Oliveira-Maia); Department of Psychiatry and Behavioral Sciences, University of South Carolina School of Medicine, Greenville (Maletic); Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford (Suppes); Department of Psychiatry, University of California, San Diego (Stahl).
During the past decade, there has been extraordinary public, media, and medical research interest in psychedelics as promising therapeutics for difficult-to-treat psychiatric disorders. Short-term controlled trial data suggest that certain psychedelics are effective and safe in the treatment of major depressive disorder, treatment-resistant depression, and posttraumatic stress disorder. Preliminary evidence also supports efficacy in other psychiatric disorders (e.
View Article and Find Full Text PDFPsychedelics in Psychiatry: Oh, What A Trip!
Am J Psychiatry
January 2025
Department of Psychiatry and Behavioral Sciences, Center for Psychedelic Research and Therapy, and Institute for Early Life Adversity Research, University of Texas at Austin Dell Medical School (Fonzo, Nemeroff); Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison (Kalin).
Research and Implementation of Psychedelic-Assisted Therapy in the Veterans Health Administration.
Am J Psychiatry
January 2025
Directorate of Behavioral Health, Walter Reed National Military Medical Center, Bethesda, Md. (Wolfgang); Department of Psychiatry, Uniformed Services University, Bethesda, Md. (Wolfgang, Benedek); Department of Psychiatry, Yale University School of Medicine, New Haven, Conn. (Wolfgang, Wiechers); Department of Veterans Affairs, Office of Research and Development, Washington, D.C. (McClair, Smyth, Tenhula); Department of Veterans Affairs, Executive Division, National Center for PTSD, White River Junction, Vt. (Schnurr, Holtzheimer); Department of Psychiatry, Geisel School of Medicine at Dartmouth, Hanover, N.H. (Schnurr, Holtzheimer); Department of Psychiatry and Behavioral Sciences, University of California, San Francisco. (Woolley, Wiechers); San Francisco Veterans Affairs Medical Center, San Francisco. (Woolley); Department of Psychiatry, Oregon Health and Science University, Portland, Ore. (Stauffer); Department of Mental Health; VA Portland Health Care System, Portland, Ore. (Stauffer); Substance Abuse and Mental Health Services Administration, Rockville, Md. (Wolf); Department of Health and Human Services, Office of the Assistant Secretary for Health, Washington, D.C. (States); Department of Psychiatry, Harvard Medical School, Boston (Bradley); VA Boston Healthcare System, Boston (Bradley); Department of Veterans Affairs, Pharmacy Benefits Management Service, Washington, D.C. (Fuller); Department of Psychiatry, Case Western Reserve University, Cleveland, Ohio (Fuller); Department of Veterans Affairs, Northeast Program Evaluation Center, Office of Mental Health, Washington, D.C. (Hermes); Veterans Health Administration Office of Mental Health, Washington, D.C. (Wiechers).
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