AI Article Synopsis
- A study investigated the differences in neuro-metabolite concentrations in the anterior cingulate cortex (ACC) between young adults with major depressive disorder (MDD) and healthy controls, focusing on two subregions: the pregenual ACC (pACC) and anterior midcingulate cortex (aMCC).
- Results showed that MDD patients had higher levels of glutamate and glutamine in the pACC and higher myo-inositol in the aMCC compared to controls, indicating pronounced metabolic changes in the MDD group.
- The findings suggest that the pACC and aMCC may have different roles in MDD, highlighting the regional metabolic differences in the ACC and contributing to
Article Abstract
Background: Previous studies have shown major depressive disorder (MDD) is associated with altered neuro-metabolites in the anterior cingulate cortex (ACC). However, the regional metabolic heterogeneity in the ACC in individuals with MDD remains unclear.
Methods: We recruited 59 first-episode, treatment-naive young adults with MDD and 50 healthy controls who underwent multi-voxel H-MRS scanning at 3 T (Tesla) with voxels placed in the ACC, which was divided into two subregions, pregenual ACC (pACC) and anterior midcingulate cortex (aMCC). Between and within-subjects metabolite concentration variations were analyzed with SPSS.
Results: Compared with control subjects, patients with MDD exhibited higher glutamate (Glu) and glutamine (Gln) levels in the pACC and higher myo-inositol (MI) level in the aMCC. We observed higher Glu and Gln levels and lower N-acetyl-aspartate (NAA) level in the pACC than those in the aMCC in both MDD and healthy control (HC) groups. More importantly, the metabolite concentration gradients of Glu, Gln and NAA were more pronounced in MDD patients relative to HCs. In the MDD group, the MI level in the aMCC positively correlated with the age of onset.
Limitations: The use of the relative concentration of metabolites constitutes a key study limitation.
Conclusions: We observed inconsistent alterations and distribution of neuro-metabolites concentration in the pACC and aMCC, revealing regional metabolic heterogeneity of ACC in first-episode, treatment-naive young individuals with MDD. These results provided new evidence for abnormal neuro-metabolites of ACC in the pathophysiology of MDD and suggested that pACC and aMCC might play different roles in MDD.
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| http://dx.doi.org/10.1016/j.jad.2022.09.001 | DOI Listing |
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