AI Article Synopsis
- The study investigated the connection between pineal parenchymal volume (PPV) and schizophrenia-like psychosis (SLP) in individuals aged 60 and older.
- Researchers compared PPV in 21 SLP patients, 50 Alzheimer's patients with delusions of theft, and 35 cognitively healthy individuals.
- Findings showed that both SLP and Alzheimer's patients had significantly lower PPVs than those with normal cognition, suggesting that reduced pineal volume may be related to very late-onset schizophrenia-like psychosis (VLOSLP).
Article Abstract
This study aimed to examine the relationship between pineal parenchymal volume (PPV) and schizophrenia-like psychosis (SLP) at the onset of ≥ 60 years. Exactly 21 patients with SLP, 50 with Alzheimer's disease (AD) with delusions of theft, and 35 with normal cognition were selected. The PPVs in patients with SLP and patients with AD with delusional theft were significantly lower than those in patients with normal cognition. Moreover, PPVs in nine patients with Very late-onset schizophrenia-like psychosis (VLOSLP) tended to be lower than that in patients with normal cognition. Thus, pineal volume reduction could be a neural correlate of VLOSLP.
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| http://dx.doi.org/10.1016/j.ajp.2022.103251 | DOI Listing |
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