Stress detection and monitoring is an active area of research with important implications for an individual's personal, professional, and social health. Current approaches for stress classification use traditional machine learning algorithms trained on features computed from multiple sensor modalities. These methods are data and computation-intensive, rely on hand-crafted features, and lack reproducibility. These limitations impede the practical use of stress detection and classification systems in the real world. To overcome these shortcomings, we propose Stressalyzer, a novel stress classification and personalization framework from single-modality sensor data without feature computation and selection. Stressalyzer uses only Electrodermal activity (EDA) sensor data while providing competitive results compared to the state-of-the-art techniques that use multiple sensor modalities and are computationally expensive due to the calculation of large number of features. Using the dataset collected in a laboratory setting from 15 subjects, our single-channel neural network-based model achieves a classification accuracy of 92.9% and an f1 score of 0.89 for binary stress classification. Our leave-one-subject-out analysis establishes the subjective nature of stress and shows that personalizing stress models using Stressalyzer significantly improves the model performance. Without model personalization, we found a performance decline in 40% of the subjects, suggesting the need for model personalization.
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http://dx.doi.org/10.1109/EMBC48229.2022.9871842 | DOI Listing |
Chem Rev
January 2025
Center for Theoretical Interdisciplinary Sciences Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325001, P. R. China.
Nanozymes have shown significant potential in cancer catalytic therapy by strategically catalyzing tumor-associated substances and metabolites into toxic reactive oxygen species (ROS) , thereby inducing oxidative stress and promoting cancer cell death. However, within the complex tumor microenvironment (TME), the rational design of nanozymes and factors like activity, reaction substrates, and the TME itself significantly influence the efficiency of ROS generation. To address these limitations, recent research has focused on exploring the factors that affect activity and developing nanozyme-based cascade catalytic systems, which can trigger two or more cascade catalytic processes within tumors, thereby producing more therapeutic substances and achieving efficient and stable cancer therapy with minimal side effects.
View Article and Find Full Text PDFPLoS One
January 2025
Department of Biology, College of Science and Humanities in Al-Kharj, Prince Sattam bin Abdulaziz University, Al-kharj, Saudi Arabia.
The Tapetum Determinant 1 (TPD1) family proteins are known to play a crucial role in the regulation of reproduction in plants, including Cenchrus americanus (pearl millet). However, members of TPD1 family proteins have not been fully identified. The current study aims to identify and characterize the TPD1 family proteins in Cenchrus americanus (L.
View Article and Find Full Text PDFMatern Child Nutr
January 2025
Department of Nursing, Faculty of Health Sciences, University of Alicante, San Vicente del Raspeig, Spain.
Parental feeding styles are an important factor influencing child development. Traditionally, they have been classified into four styles based on cut-off points for responsiveness and demandingness. However, alternative methods, such as latent class analysis (LCA), allow for the detection of underlying homogeneous populations.
View Article and Find Full Text PDFBrief Bioinform
November 2024
State Key Laboratory of Cellular Stress Biology, Xiang'an Hospital, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, No. 4221, Xiang'an South Road, Xiamen, Fujian 361102, China.
Acute myeloid leukemia (AML) demonstrates significant cellular heterogeneity in both leukemic and immune cells, providing valuable insights into clinical outcomes. Here, we constructed an AML single-cell transcriptome atlas and proposed sciNMF workflow to systematically dissect underlying cellular heterogeneity. Notably, sciNMF identified 26 leukemic and immune cell states that linked to clinical variables, mutations, and prognosis.
View Article and Find Full Text PDFBMC Genomics
January 2025
Henan Collaborative Innovation Center of Modern Biological Breeding, College of Agronomy, Henan Institute of Science and Technology, Xinxiang, 453003, China.
Background: The Sec14 domain is an ancient lipid-binding domain that evolved from yeast Sec14p and performs complex lipid-mediated regulatory functions in subcellular organelles and intracellular traffic. The Sec14 family is characterized by a highly conserved Sec14 domain, and is ubiquitously expressed in all eukaryotic cells and has diverse functions. However, the number and characteristics of Sec14 homologous genes in soybean, as well as their potential roles, remain understudied.
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