Channel suppression can reduce the redundant information in multiple channel receiver coils and accelerate reconstruction speed to meet real-time imaging requirements. The principal component analysis has been used for channel suppression, but it is difficult to be interpreted because all channels contribute to principal components. Furthermore, the importance of interpretability in machine learning has recently attracted increasing attention in radiology. To improve the interpretability of PCA-based channel suppression, a sparse PCA method is proposed to reduce the most coils' loadings to be zero. Channel suppression is formulated as solving a nonlinear eigenvalue problem using the inverse power method instead of the direct matrix decomposition. Experimental results of in vivo data show that the sparse PCA-based channel suppression not only improves the interpretability with sparse channels, but also improves reconstruction quality compared to the standard PCA-based reconstruction with the similar reconstruction time.
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http://dx.doi.org/10.1109/EMBC48229.2022.9871474 | DOI Listing |
Adv Sci (Weinh)
January 2025
College of Optical Science and Engineering, Zhejiang University, Hangzhou, 310058, China.
Photonic manipulation of large-capacity data with the advantages of high speed and low power consumption is a promising solution for explosive growth demands in the era of post-Moore. A well-developed lithium-niobate-on-insulator (LNOI) platform has been widely explored for high-performance electro-optic (EO) modulators to bridge electrical and optical signals. However, the photonic waveguides on the x-cut LNOI platform suffer serious polarization-mode conversion/coupling issues because of strong birefringence, making it hard to realize large-scale integration.
View Article and Find Full Text PDFAnal Chem
January 2025
Institute for Advanced Optics, Hunan Institute of Science and Technology, Yueyang, Hunan 414006, China.
Diffraction imaging of cells allows rapid phenotyping by the response of intracellular molecules to coherent illumination. However, its ability to distinguish numerous types of human leukocytes remains to be investigated. Here, we show that accurate classification of three lymphocyte subtypes can be achieved with features extracted from cross-polarized diffraction image (p-DI) pairs.
View Article and Find Full Text PDFJ Inorg Biochem
December 2024
Rutgers, The State University of New Jersey, Dept of Pharmacology, Physiology & Neuroscience, Newark, NJ, United States of America.
Crown ethers have been shown to have physiological effects ascribed to their ionophoric properties. However, high levels of toxicity precluded interest in their evaluation as therapeutic agents. We prepared new silacrown analogs of crown ethers.
View Article and Find Full Text PDFEur J Neurol
January 2025
Department of Pharmacotherapy, University of Utah Health, Salt Lake City, Utah, USA.
Background: Reduction of intracellular Na accumulation through late Na current inhibition has been recognized as a target for cardiac Ca handling which underlies myocardial contractility and relaxation in heart failure (HF). Riluzole, an Na channel blocker with enhancement of Ca-activated K channel function, used for management of amyotrophic lateral sclerosis (ALS), is effective in suppressing Ca leak and therefore may improve cardiac function.
Objectives: The study aim was to investigate whether riluzole lowers HF incidence.
FASEB J
January 2025
Department of Orthopaedic Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.
Osteoarthritis (OA) is characterized by articular cartilage degeneration, leading to pain and loss of joint function. Recent studies have demonstrated that omega-3 (ω3) polyunsaturated fatty acid (PUFA) supplementation can decrease injury-induced OA progression in mice fed a high-fat diet. Furthermore, PUFAs have been shown to influence the mechanical properties of chondrocyte membranes, suggesting that alterations in mechanosensitive ion channel signaling could contribute to the mechanism by which ω3 PUFAs decreased OA pathogenesis.
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