AI Article Synopsis
- * There has been a challenge in detecting NO non-invasively at the inflammation site despite its potential for diagnosis.
- * This study introduces a capsule-like electrochemical gas sensor that successfully detects NO directly at the inflammation site in an animal model, highlighting its importance in monitoring the condition.
Article Abstract
More than two decades ago it was discovered that nitric oxide (NO) concentrations in gas aspirated during colonoscopy were more than 100 times higher in patients diagnosed with Ulcerative Colitis (UC) than controls. While this provides a diagnostic opportunity, it has not been possible to perform in situ detection of NO via a non-invasive manner. This work presents the feasibility of in situ detection of NO by means of a capsule-like electrochemical gas sensor. Our in vivo results in a large animal model of intestinal inflammation show that NO can be directly detected at the site of inflammation and that it quickly dissipates to surrounding tissues, demonstrating the importance of in situ detection.
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| http://dx.doi.org/10.1109/EMBC48229.2022.9871468 | DOI Listing |
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