A cognitive and physical stress co-classification effort started with acquisition of a training dataset and generation of machine learning models from 17 heart rate variability parameters. Accuracy was improved with multilayer perceptron models and tested on 85 firefighters in a cage maze. A specific platform acquired a dataset with better label accuracy providing a second model. Feature importance and model performance were assessed using the cage maze data. A SHAP analysis provided the basis for the model comparison and feature important assessment. Conclusions were drawn on best time windows, feature selection, and model hyperparameters.
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http://dx.doi.org/10.1109/EMBC48229.2022.9871470 | DOI Listing |
Biomolecules
January 2025
Research and Education Resource Center, Peoples Friendship University of Russia (RUDN University), 117198 Moscow, Russia.
Post-translational modifications of proteins via palmitoylation, a thioester linkage of a 16-carbon fatty acid to a cysteine residue, reversibly increases their affinity for cholesterol-rich lipid rafts in membranes, changing their function. Little is known about how altered palmitoylation affects function at the systemic level and contributes to CNS pathology. However, recent studies suggested a role for the downregulation of palmitoyl acetyltransferase (DHHC) 21 gene expression in the development of Major Depressive Disorder (MDD)-like syndrome.
View Article and Find Full Text PDFFront Psychol
October 2024
Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, Department of Anesthesiology and Pain Medicine, Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Objective: The causal link between detrimental behaviors and cognitive performance remains unclear. This research seeks to investigate the causal impact of adjustable lifestyle factors on cognitive deterioration, including frequency of alcohol intake, onset of smoking, and sedentary activities like prolonged television viewing.
Methods: This research combines large-scale genetic data obtained from univariable and multivariable Mendelian randomization analyses with experimental findings obtained from animal models.
J Inflamm (Lond)
October 2024
iNOVA4Health, NOVA Medical School | Faculdade Ciências Médicas, NMS|FCM, Universidade Nova de Lisboa, Campo dos Mártires da Pátria, Lisboa, Portugal.
Lipopolysaccharide (LPS) challenge in mice has been used to identify the mechanisms and therapeutics for neuroinflammation. In this study, we aimed to comprehensively evaluate the behavioral changes including locomotion, exploration, and memory, correlating them with a panel of thirteen inflammatory cytokines in both blood and brain.We found that acute LPS administration (0.
View Article and Find Full Text PDFJ Integr Neurosci
September 2024
Department of Neurobiology, Groningen Institute for Evolutionary Life Sciences (GELIFES), University of Groningen, 9747 AG Groningen, The Netherlands.
Background: Beneficial effects of whole-body vibration (WBV) on brain and musculoskeletal health in mice have been demonstrated, but underlying mechanisms remain relatively unrevealed. WBV improves attention and memory performance in mice, putatively through stimulation of the cholinergic system. Here, we investigated the effects of WBV on the septo-hippocampal cholinergic system.
View Article and Find Full Text PDFBiomedicines
August 2024
Institut des Neurosciences Paris-Saclay (NeuroPSI), Université Paris-Saclay, CNRS, CEA Paris-Saclay, bât 151, 91400 Saclay, France.
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