Causality in cardiorespiratory signals in pediatric cardiac patients.

Four different Granger causality-based methods - one linear and three nonlinear (Granger Causality, Kernel Granger Causality, large-scale Nonlinear Granger Causality, and Neural Network Granger Causality) were used for assessment and causal-based quantification of the respiratory sinus arrythmia (RSA) in the group of pediatric cardiac patients, based on the single-lead ECG and impedance pneumography signals (the latter as the tidal volume curve equivalent). Each method was able to detect the dependency (in terms of causal inference) between respiratory and cardiac signals. The correlations between quantified RSA and the demographic parameters were also studied, but the results differ for each method. Clinical relevance- The presented methods (among which NNGC seems to be the most valid) allow for quantification of RSA and study of dependency between tidal volume and RR intervals which may help to better understand association between respiratory and cardiovascular systems in different populations.