Colorectal cancer is the third most incidence cancer world-around. Colonoscopies are the most effective resource to detect and segment abnormal polyp masses, considered as the main biomarker of this cancer. Nonetheless, some recent clinical studies have revealed a polyp miss rate up to 26% during the clinical routine. Also, the expert bias introduced during polyp shape characterization may induce to false-negative diagnosis. Current computational approaches have supported polyp segmentation but over controlled scenarios, where polyp frames have been labeled by an expert. These supervised representations are fully dependent of well-segmented polyps, in crop sequences that always report these masses. This work introduces an attention receptive field mechanism, that robustly recover the polyp shape, by learning non-local pixel relationship. Besides this deep representation is learning from a weakly supervised scheme that includes unlabeled background frames, to discriminate polyps from near structures like intestinal folds. The achieved results outperform state-of-the-art approaches achieving a 95.1% precision in the public CVC-Colon DB, with also competitive performance on other datasets. Clinical relevance-The work address a novel strategy to support segmentation tools in a clinical routine with redundant background over colonoscopy sequences.
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http://dx.doi.org/10.1109/EMBC48229.2022.9871158 | DOI Listing |
JAMIA Open
February 2025
Hasso Plattner Institute for Digital Engineering, University of Potsdam, Potsdam 14482, Germany.
Objective: To improve performance of medical entity normalization across many languages, especially when fewer language resources are available compared to English.
Materials And Methods: We propose xMEN, a modular system for cross-lingual (x) medical entity normalization (MEN), accommodating both low- and high-resource scenarios. To account for the scarcity of aliases for many target languages and terminologies, we leverage multilingual aliases via cross-lingual candidate generation.
Am J Pathol
December 2024
Department of Computer Science, Faculty of Engineering Sciences, University College London, Gower Street, London, WC1E 6BT, United Kingdom.
Understanding the tumor hypoxic microenvironment is crucial for grasping tumor biology, clinical progression, and treatment responses. This study presents a novel application of AI in computational histopathology to evaluate hypoxia in breast cancer. Weakly Supervised Deep Learning (WSDL) models can accurately detect morphological changes associated with hypoxia in routine Hematoxylin and Eosin (H&E) whole slide images (WSI).
View Article and Find Full Text PDFSci Rep
December 2024
Electronic Engineering College, Heilongjiang University, Harbin, 150080, China.
With the rapid development of the semiconductor industry, Hardware Trojans (HT) as a kind of malicious function that can be implanted at will in all processes of integrated circuit design, manufacturing, and deployment have become a great threat in the field of hardware security. Side-channel analysis is widely used in the detection of HT due to its high efficiency, non-contact nature, and accuracy. In this paper, we propose a framework for HT detection based on contrastive learning using power consumption information in unsupervised or weakly supervised scenarios.
View Article and Find Full Text PDFFront Med (Lausanne)
December 2024
Department of Pathology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Introduction: Thymoma classification is challenging due to its diverse morphology. Accurate classification is crucial for diagnosis, but current methods often struggle with complex tumor subtypes. This study presents an AI-assisted diagnostic model that combines weakly supervised learning with a divide-and-conquer multi-instance learning (MIL) approach to improve classification accuracy and interpretability.
View Article and Find Full Text PDFJ Pathol Inform
December 2024
Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, Lisbon 1049-001, Portugal.
Whole slide images (WSI), obtained by high-resolution digital scanning of microscope slides at multiple scales, are the cornerstone of modern Digital Pathology. However, they represent a particular challenge to artificial intelligence (AI)-based/AI-mediated analysis because pathology labeling is typically done at slide-level, instead of tile-level. It is not just that medical diagnostics is recorded at the specimen level, the detection of oncogene mutation is also experimentally obtained, and recorded by initiatives like The Cancer Genome Atlas (TCGA), at the slide level.
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