AI Article Synopsis
- Next-generation sequencing and single-cell RNA sequencing (scRNA-seq) have rapidly advanced, offering insights into the gene expression specific to individual cell types.
- These technologies help understand cell diversity, responses to disease, and related biological mechanisms, making significant impacts in medical and biomedical fields.
- Despite its potential, scRNA-seq has yet to gain traction in forensic medicine, and the authors propose exploring its applications to enhance forensic research and broaden the field.
Article Abstract
Next-generation sequencing and single-cell RNA sequencing (scRNA-seq) technologies have advanced rapidly in recent years. scRNA-seq reveals the unique gene expression of each cell type, providing directions for exploring cell heterogeneity, cell type-specific responses to injury/disease, and the mechanisms underlying these processes. The development of sequencing technology and improved sequencing throughput have brought about a revolution in single-cell transcriptome study, bringing great benefits to the fields of medicine and biomedical science. From our perspective, certain issues in forensic medicine may potentially be addressed using single-cell transcriptome studies; however, this powerful technique has not yet attracted sufficient attention in forensic medicine-associated research. Therefore, examining and reviewing the latest developments and applications of single-cell transcriptome studies, we present our views on the future directions of forensic research using this technology, aiming to expand the frontiers of forensic science.
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| http://dx.doi.org/10.1007/s00414-022-02889-9 | DOI Listing |
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