Background: It remains unclear whether lateral joint space narrowing without severe cartilage loss before meniscal allograft transplantation (MAT) affects clinical outcomes and graft extrusion.
Hypothesis: Patients with greater preoperative joint space narrowing would show more graft extrusion, more osteoarthritis progression, and worse clinical outcomes than would those with less narrowing.
Study Design: Case-control study; Level of evidence, 3.
Methods: We retrospectively evaluated 61 patients who underwent lateral MAT and had a minimum follow-up of 4 to 5 years. The median preoperative joint space width (JSW) on Rosenberg view radiographs was used to classify patients into those with less joint space narrowing (JSW ≥3 mm; group A) and greater joint space narrowing (JSW <3 mm; group B). We compared differences between groups in terms of graft extrusion and articular cartilage loss (modified Outerbridge grade ≥3) on 1-year postoperative magnetic resonance imaging (MRI) scans and changes in JSW and clinical outcomes at the last follow-up.
Results: There were 31 patients in group A and 30 patients in group B; the mean follow-up time for all patients was 64.4 ± 10.3 months. All patients showed a significant preoperative to postoperative improvement in outcome scores ( < .001 for all). The mean preoperative JSW was 3.8 ± 0.9 mm in group A and 2.3 ± 0.4 mm in group B ( < .001). In group B, there was more graft extrusion on postoperative MRI scans (3.0 ± 0.9 vs 1.9 ± 0.6 mm, respectively; < .001) and a higher proportion of patients with pathological graft extrusion at final follow-up (43.3% vs 12.9%, respectively; = .011) compared with group A. At 1 year postoperatively, cartilage loss grade ≥3 was observed at the lateral femoral condyle in 3.2% and 20.0% of patients in groups A and B ( = .053), respectively, and at the lateral tibial plateau in 3.2% and 30.0% of patients ( = .006), respectively. There were moderate correlations between graft extrusion and preoperative absolute JSW ( = -0.471; < .001) and preoperative relative JSW ( = -0.428; = .001).
Conclusion: Patients with less preoperative joint space narrowing had less graft extrusion and cartilage loss on 1-year postoperative MRI scans, as well as better radiological and clinical outcomes at midterm follow-up, compared with patients with greater preoperative narrowing.
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http://dx.doi.org/10.1177/23259671221103845 | DOI Listing |
Space Sci Rev
January 2025
Dept. of Space and Climate Physics, MSSL/UCL, Mullard Space Science Laboratory, University College London, Holmbury St. Mary, Dorking, Surrey RH5 6NT UK.
The Solar wind Magnetosphere Ionosphere Link Explorer (SMILE) was proposed to the Chinese Academy of Science (CAS) and the European Space Agency (ESA) following a joint call for science missions issued in January 2015. SMILE was proposed by a team of European and Chinese scientists, led by two mission Co-PIs, one from China and one from Europe. SMILE was selected in June 2015, and its budget adopted by the Chinese Academy of Sciences in November 2016 and the ESA Science Programme Committee in March 2019, respectively.
View Article and Find Full Text PDFNat Commun
January 2025
ZJU-UIUC Institute, Interdisciplinary Center for Quantum Information, State Key Laboratory of Extreme Photonics and Instrumentation, Zhejiang University, Hangzhou, China.
The bidirectional interactions between metamaterials and artificial intelligence have recently attracted immense interest to motivate scientists to revisit respective communities, giving rise to the proliferation of intelligent metamaterials and metamaterials intelligence. Owning to the strong nonlinear fitting and generalization ability, artificial intelligence is poised to serve as a materials-savvy surrogate electromagnetic simulator and a high-speed computing nucleus that drives numerous self-driving metamaterial applications, such as invisibility cloak, imaging, detection, and wireless communication. In turn, metamaterials create a versatile electromagnetic manipulator for wave-based analogue computing to be complementary with conventional electronic computing.
View Article and Find Full Text PDFJ Arthroplasty
January 2025
Orthopedic Surgery Artificial Intelligence Laboratory, Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA; Mayo Clinic Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA. Electronic address:
Background: Minimum joint space width (mJSW) is an important continuous quantitative metric of osteoarthritis progression in the knee. The purpose of this study was to develop an automated measurement algorithm for mJSW in the medial and lateral compartments of the knee that can flexibly handle native knees as well as knees after arthroplasty.
Methods: We developed an end-to-end algorithm consisting of a deep learning segmentation model plus a computer vision algorithm to measure mJSW in the medial and lateral compartments of the knee.
Front Sociol
January 2025
School of Education, Humanities and Social Sciences, Halmstad University, Halmstad, Sweden.
The article analyses how a norm scientific perspective can advance our understanding of cross-border regions and guide future directions of research. Cross-border regions are territorial spaces comprising territory from two or more national states, located directly at the borders of those spaces. Since the 1950s it has become increasingly common that cross-border organizations, constituted by local municipalities and regional authorities and sometimes private entities, are established to coordinate governance processes around shared policy problems.
View Article and Find Full Text PDFJ Dent Res
January 2025
Department of Preventive and Restorative Dental Sciences, School of Dentistry, University of California, San Francisco, CA, USA.
The upstream mechanobiological pathways that regulate the downstream mineralization rates in periodontal tissues are limitedly understood. Herein, we spatially colocalized and correlated compression and tension strain profiles with the expressions of mechanosensory ion channels (MS-ion) TRPV4 and PIEZO1, biometal zinc, mitochondrial function marker (), cell senescence indicator (), and oxygen status marker hypoxia-inducible factor-1α () in rats fed hard and soft foods. The observed zinc and related cellular homeostasis in vivo were ascertained by TRPV4 and PIEZO1 agonists and antagonists on human periodontal ligament fibroblasts ex vivo.
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