The Internet of Things includes all connected objects from small embedded systems with low computational power and storage capacities to efficient ones, as well as moving objects like drones and autonomous vehicles. The concept of Internet of Everything expands upon this idea by adding people, data and processing. The adoption of such systems is exploding and becoming ever more significant, bringing with it questions related to the security and the privacy of these objects. A natural solution to data integrity, confidentiality and single point of failure vulnerability is the use of blockchains. Blockchains can be used as an immutable data layer for storing information, avoiding single point of failure vulnerability via decentralization and providing strong security and cryptographic tools for IoE. However, the adoption of blockchain technology in such heterogeneous systems containing light devices presents several challenges and practical issues that need to be overcome. Indeed, most of the solutions proposed to adapt blockchains to devices with low resources confront difficulty in maintaining decentralization or security. The most interesting are probably the Layer 2 solutions, which build offchain systems strongly connected to the blockchain. Among these, zk-rollup is a promising new generation of Layer 2/off-chain schemes that can remove the last obstacles to blockchain adoption in IoT, or more generally, in IoE. By increasing the scalability and enabling rule customization while preserving the same security as the Layer 1 blockchain, zk-rollups overcome restrictions on the use of blockchains for IoE. Despite their promises illustrated by recent systems proposed by startups and private companies, very few scientific publications explaining or applying this barely-known technology have been published, especially for non-financial systems. In this context, the objective of our paper is to fill this gap for IoE systems in two steps. We first propose a synthetic review of recent proposals to improve scalability including onchain (consensus, blockchain organization, …) and offchain (sidechain, rollups) solutions and we demonstrate that zk-rollups are the most promising ones. In a second step, we focus on IoE by describing several interesting features (scalability, dynamicity, data management, …) that are illustrated with various general IoE use cases.
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http://dx.doi.org/10.3390/s22176493 | DOI Listing |
BMC Geriatr
December 2024
ZHAW Zurich University of Applied Sciences, Winterthur Institute of Health Economics, Winterthur, Switzerland.
Background: Fall prevention programmes are essential interventions in societies with aging populations. This study assessed the fall rate and other health outcomes, as well as the cost-effectiveness of a home-based fall prevention programme for community-dwelling older people. In a single home visit, trained physical or occupational therapists performed fall risk assessments, eliminated environmental risk factors, and provided tailored exercises.
View Article and Find Full Text PDFCardiovasc Revasc Med
December 2024
Department of Cardiology and Catheterization Laboratories, Shonan Kamakura General Hospital, Okamoto 1370-1, Kamakura City, Kanagawa 247-8533, Japan. Electronic address:
Background/purpose: Transcatheter aortic valve replacement (TAVR) with ACURATE neo2 showed better hemodynamic outcomes by mitigating paravalvular leakage (PVL) compared with ACURATE neo, and revealed promising one-year outcomes in single-arm studies. However, studies comparing the hemodynamic and clinical outcomes of the two valves are still scarce. Therefore, this study aimed to compare the one-year hemodynamic and clinical outcomes between the neo2 and neo.
View Article and Find Full Text PDFWorld Neurosurg
December 2024
Department of Neurology, Nanjing Pukou People's Hospital, No. 166 Shanghe Street, Jiangpu Subdistrict, Pukou District, Nanjing, 210000, China. Electronic address:
Objective: Early identification of risk factors associated with early neurological deterioration (END) in patients with acute minor stroke and large vessel occlusion (LVO) receiving intravenous thrombolysis (IVT) could assist in formulating treatment decisions.
Methods: Consecutive patients with acute minor stroke and LVO were extracted from a single-center prospective database spanning January 2020 to December 2023. END was defined as an increase of ≥ 4 points in the National Institutes of Health Stroke Scale (NIHSS) score from baseline, or ≥ 2 points in any single NIHSS item, within 24 hours of the IVT.
SLAS Technol
December 2024
Center for Biomedical Engineering, School of Engineering, Brown University, Providence, RI 02912, USA. Electronic address:
Automated liquid handlers are fundamental in modern life science laboratories, yet their high costs and large footprints often limit accessibility for smaller labs. This study presents an innovative approach to decentralizing a liquid handling system by converting a low-cost 3D printer into a customizable and accurate liquid handler. The Personal Automated Liquid Handler (PALH) system, costing ∼$400, incorporates a single-channel pipet, custom 3D-printed components, and open-source software for personalized workflows, allowing researchers to build and modify the system for specific experimental needs.
View Article and Find Full Text PDFInt J Biol Macromol
December 2024
Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, TEDA Institute of Biological Sciences and Biotechnology, Nankai University, TEDA, Tianjin 300457, PR China; Tianjin Key Laboratory of Microbial Functional Genomics, Tianjin 300457, PR China. Electronic address:
The robustness and catalytic activity of superoxide dismutase (SOD) are still the main factors limiting their application in industrial fields. This study aims to further improve the properties of a natural thermophilic iron/manganese dual-domain SOD (Fe/Mn-SODA fused with N-terminal polypeptide) from Geobacillus thermodenitrificans NG80-2 (GtSOD) by modifying its each domain using in-depth in silico prediction analysis as well as protein engineering. First, computational analysis of the N-terminal domain and GtSODA domain was respectively performed by using homologous sequence alignment and virtual mutagenesis.
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