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Chronic Treatment with Melatonin Improves Hippocampal Neurogenesis in the Aged Brain and Under Neurodegeneration. | LitMetric

AI Article Synopsis

  • Aging and neurodegenerative diseases disrupt normal hippocampal neurogenesis, leading to issues like damaged neurons and β-amyloid accumulation in the brains of SAMP8 mice, a model for accelerated aging and Alzheimer's pathology.
  • Chronic melatonin treatment (over 9 months) showed neuroprotective effects, reducing markers of neurodegeneration and improving cell survival and maturation in the hippocampus.
  • The study suggests that melatonin can enhance adult hippocampal neurogenesis, offering potential therapeutic benefits for age-related cognitive decline and neurodegenerative conditions.

Article Abstract

Adult hippocampal neurogenesis is altered during aging and under different neuropsychiatric and neurodegenerative diseases. Melatonin shows neurogenic and neuroprotective properties during aging and neuropathological conditions. In this study, we evaluated the effects of chronic treatment with melatonin on different markers of neurodegeneration and hippocampal neurogenesis using immunohistochemistry in the aged and neurodegenerative brains of SAMP8 mice, which is an animal model of accelerated senescence that mimics aging-related Alzheimer's pathology. Neurodegenerative processes observed in the brains of aged SAMP8 mice at 10 months of age include the presence of damaged neurons, disorganization in the layers of the brain cortex, alterations in neural processes and the length of neuronal prolongations and β-amyloid accumulation in the cortex and hippocampus. This neurodegeneration may be associated with neurogenic responses in the hippocampal dentate gyrus of these mice, since we observed a neurogenic niche of neural stem and progenitor/precursors cells in the hippocampus of SAMP8 mice. However, hippocampal neurogenesis seems to be compromised due to alterations in the cell survival, migration and/or neuronal maturation of neural precursor cells due to the neurodegeneration levels in these mice. Chronic treatment with melatonin for 9 months decreased these neurodegenerative processes and the neurodegeneration-induced neurogenic response. Noticeably, melatonin also induced recovery in the functionality of adult hippocampal neurogenesis in aged SAMP8 mice.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9457692PMC
http://dx.doi.org/10.3390/molecules27175543DOI Listing

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