There are clearly numerous examples of mediation pathology in surgery. They go far beyond what may be defined as severe forms, in which the entire body is involved in the precipitating disease process and in which the mediation appears more easily recognizable, in that it evokes a resonance which wipes out all specificity and becomes the true protagonist of the critical situation. Forms which can be traced to a well defined pathogenesis, and others to a more debatable pathogenesis, afford great scope for mediation. May one, for instance, be justified in suggesting a mediation hypothesis for a classic surgical disease such as duodenal ulcer?

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