AI Article Synopsis
- The study focused on identifying chronic migraine patients who might benefit the most from onabotulinumtoxinA treatments, analyzing response rates in a multicenter European setting.
- Excellent responders were categorized as those with either a significant drop in headache days (≥75%) or those experiencing infrequent headaches (<4 days/month), with about 10% and 5% of patients classified in each category, respectively.
- Key findings indicated that excellent responders tended to have higher medication overuse and that female patients were less likely to be categorized as frequency-based excellent responders, suggesting that those without medication overuse or female patients might see less benefit from the treatment.
Article Abstract
The identification of patients who can benefit the most from the available preventive treatments is important in chronic migraine. We explored the rate of excellent responders to onabotulinumtoxinA in a multicenter European study and explored the predictors of such response, according to different definitions. A pooled analysis on chronic migraineurs treated with onabotulinumtoxinA and followed-up for, at least, 9 months was performed. Excellent responders were defined either as patients with a ≥75% decrease in monthly headache days (percent-based excellent responders) or as patients with <4 monthly headache days (frequency-based excellent responders). The characteristics of excellent responders at the baseline were compared with the ones of patients with a <30% decrease in monthly headache days. Percent-based excellent responders represented about 10% of the sample, whilst frequency-based excellent responders were about 5% of the sample. Compared with non-responders, percent-based excellent responders had a higher prevalence of medication overuse and a higher excellent response rate even after the 1st and the 2nd injection. Females were less like to be frequency-based excellent responders. Chronic migraine sufferers without medication overuse and of female sex may find fewer benefits with onabotulinumtoxinA. Additionally, the excellent response status is identifiable after the first cycle.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9518492 | PMC |
| http://dx.doi.org/10.3390/ijerph191710975 | DOI Listing |
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